675833-69-9Relevant articles and documents
The discovery of glycine and related amino acid-based factor Xa inhibitors
Kohrt, Jeffrey T.,Filipski, Kevin J.,Cody, Wayne L.,Bigge, Christopher F.,La, Frances,Welch, Kathleen,Dahring, Tawny,Bryant, John W.,Leonard, Daniele,Bolton, Gary,Narasimhan, Lakshmi,Zhang, Erli,Peterson, J. Thomas,Haarer, Staci,Sahasrabudhe, Vaishali,Janiczek, Nancy,Desiraju, Shrilakshmi,Hena, Mostofa,Fiakpui, Charles,Saraswat, Neerja,Sharma, Raman,Sun, Shaoyi,Maiti, Samarendra N.,Leadley, Robert,Edmunds, Jeremy J.
, p. 4379 - 4392 (2007/10/03)
Herein, we report on the identification of three potent glycine and related amino acid-based series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray crystal structure has shown that constrained glycine derivatives with optimiz
