676095-45-7Relevant articles and documents
The chemistry of tetrafluoroallene: Nucleophilic addition reactions with phenols and amines
Xiao, Ji-Chang,Chen, Qing-Yun
, p. 189 - 195 (2003)
Treatment of tetrafluoroallene or its precursor, ICF2 CH2CF2I, with phenols in the presence of K2CO3 gave the corresponding unsaturated ethers. Tetrafluoroallene also reacted readily with amines in TH
Copper-Catalyzed Selective Defluorinative Sulfuration of Trifluoropropanamides Leading to α-Fluorothioacrylamides
Shen, Xiao-Qin,Wang, Sui-Qian,Fan, Dongfeng,Zhang, Xing-Guo,Tu, Hai-Yong
, p. 1591 - 1600 (2021/01/13)
A practical and efficient method for the synthesis of α-fluorothioacrylamide was developed from selective defluorinative sulfuration of trifluoropropanamides with disulfides. The N-chelation-assisted copper-catalyzed defluorination and sulfurization reactions feature excellent functional group tolerance and incorporation of both sulfur atoms of disulfides into acrylamides.
An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification
Dubowchik, Gene M.,Michne, Jodi A.,Zuev, Dmitry
, p. 3147 - 3149 (2007/10/03)
Collections of small secondary amines for compound library generation can be efficiently prepared by amide reduction using BH3-THF or Red-Al followed by brief methanolysis, trapping with di-tert-butyl dicarbonate, and deprotection with 4M HCl i
