67625-35-8

Basic information

• Product Name: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 5-METHYLIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-methyl-imidazo[1,2-a] pyridine-2-;5-METHYLIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER, 95+%;5-Methylimidazo[1,2-α]pyridine-2-carboxylic Acid Ethyl Ester;5-methylimidazo[1,2-a]pyridine-2-carboxylate
• CAS NO: 67625-35-8
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: blocks;Bromides;Imidazoles;Pyridines;Building Blocks;C11;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Heterocycle-Pyridine series
• Mol File: 67625-35-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 134-135
• Appearance: /
• Density: 1.19 g/cm³
• Refractive Index: 1.584
• PKA: 3.92±0.50(Predicted)
• CAS DataBase Reference: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(67625-35-8)
• EPA Substance Registry System: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(67625-35-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 67625-35-8(Hazardous Substances Data)

Usage

General Description

5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is a chemical compound with the molecular formula C11H11N3O2. It is an ethyl ester derivative of 5-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid, which is a heterocyclic compound with potential pharmaceutical and biological properties. This chemical is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds. It is also used in the research and development of new drug candidates and potential therapeutic agents. Additionally, 5-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester may have other industrial and laboratory applications, but its specific uses and properties may vary depending on the intended application.

InChI:InChI=1/C11H12N2O2/c1-3-15-11(14)9-7-13-8(2)5-4-6-10(13)12-9/h4-7H,3H2,1-2H3

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 118001-83-5 4-[(E)-2-(5-Methyl-imidazo[1,2-a]pyridin-2-yl)-vinyl]-benzonitrile 
• 872363-02-5 (5-methylimidazo[1,2-a]pyridin-2-yl)methanol 
• 88751-06-8 5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid 
• 859788-72-0 3-(2-ethoxy-phenyl)-5-methyl-2H-2,4,4b,9-tetraaza-fluoren-1-one 
• 859788-43-5 3-(2-ethoxy-benzoylamino)-5-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid amide 
• 859788-98-0 5-bromomethyl-3-(2-ethoxy-phenyl)-2H-2,4,4b,9-tetraaza-fluoren-1-one 
• 118000-44-5 5-methylimidazo[1,2-a]pyridine-2-carbaldehyde 
• 118001-86-8 4-[(E)-2-(5-Methyl-imidazo[1,2-a]pyridin-2-yl)-vinyl]-benzaldehyde 
• 1123167-64-5 3-Bromo-5-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester 

Relevant articles and documents

Enantioselective Hydrogenation of Imidazo[1,2-a]pyridines

The enantioselective synthesis of tetrahydroimidazo[1,2-a]pyridines by direct hydrogenation was achieved using a ruthenium/N-heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups. 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridines, which are found in numerous bioactive molecules, were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional molecules.

SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS

The present invention provides fused derivatives of Formula (I) that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PBKs including, for example, inflammatory disorders, immune- based disorders, cancer, and other diseases.

NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to novel compounds of formula (I) wherein W, n, X and W’ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors - subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.