67627-99-0Relevant articles and documents
Straightforward and Highly Stereoselective Synthesis of 3,3,4-Trifluoropyrrolidines Involving 1,3-Dipolar Cycloaddition with 2,3,3-Trifluoroacrylate
Yamada, Shigeyuki,Higashi, Masao,Konno, Tsutomu,Ishihara, Takashi
, p. 4561 - 4568 (2016)
The reactions of benzyl 2,3,3-trifluoroacrylate with azomethine ylides, generated by the treatment of imino esters with lithium diisopropylamide, took place smoothly to give the corresponding 1,3-dipolar cycloadducts, fluorine-containing pyrrolidines, in good yields and with high diastereoselectivities (>95:5). When the fluorinated acrylate bore a chiral auxiliary as a substituent, for instance (l)-(–)-menthyl ester, the 1,3-dipolar cycloaddition reaction was found to give the corresponding fluorinated pyrrolidine derivatives in not only a diastereoselective but also an enantioselective manner.
Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines
Decuyper, Lena,Juki?, Marko,Sosi?, Izidor,Amoroso, Ana Maria,Verlaine, Olivier,Joris, Bernard,Gobec, Stanislav,D'hooghe, Matthias
supporting information, p. 51 - 55 (2019/11/28)
Monocyclic β-lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six-step synthetic route was developed, providing easy access to new 3-amino-1-carboxymethyl-4-phenyl-β-lactams, of which the penicillin-binding protein (PBP) inhibitory potency was demonstrated biochemically.
HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS
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Page/Page column 25, (2018/07/29)
The present invention is directed to compounds of Formula I, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.