67639-58-1

Basic information

• Product Name: 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE
• Synonyms: 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE;2-Bromo-5'-bromo-2'-methoxyacetophenone
• CAS NO: 67639-58-1
• Molecular Formula: C₉H₈Br₂O₂
• Molecular Weight: 307.97
• Mol File: 67639-58-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 87-89°C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE(67639-58-1)
• EPA Substance Registry System: 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE(67639-58-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 67639-58-1(Hazardous Substances Data)

Usage

Description

2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE is an organic compound characterized by its unique structure, featuring a bromo-ketone group and a bromo-methoxyphenyl moiety. 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE is known for its potential applications in the synthesis of various organic molecules, particularly in the field of pharmaceutical chemistry.

Uses

Used in Pharmaceutical Industry:
2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE is used as an intermediate in the asymmetric synthesis of 2-arylpiperazines. These 2-arylpiperazines are important building blocks for the development of pharmaceutical compounds, as they possess a wide range of biological activities and can be used to create new drugs with improved therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE serves as a versatile starting material for the preparation of various organic molecules. Its unique structure allows for selective functionalization and modification, enabling the synthesis of complex organic compounds with potential applications in various industries, such as agrochemicals, dyes, and materials science.

Upstream product

• 31949-21-0 bromomethyl 2-methoxyphenyl ketone 
• 16740-73-1 5-bromo-2-methoxyacetophenone 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 14804-32-1 2-ethylanisole 

Downstream Products

• 129486-47-1 4-(5-bromo-2-methoxyphenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole 
• 130623-10-8 1-(5-Bromo-2-methoxy-phenyl)-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-ethanone; hydrobromide 
• 874130-76-4 dithiocarbonic acid S-[2-(5-bromo-2-methoxyphenyl)-2-oxoethyl] ester O-ethyl ester 
• 130623-33-5 3-(5-Bromo-2-methoxy-phenyl)-5,6-dihydro-imidazo[2,1-b]thiazole; hydrobromide 
• 129486-32-4 4-(2-methoxyphenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole 
• 1077629-36-7 [4-(4-bromo-imidazol-1-yl)-3-methoxy-phenyl]-[4-(5-bromo-2-methoxy-phenyl)-thiazol-2-yl]-amine 
• 898392-98-8 2-(5-bromo-2-methoxyphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 1427035-08-2 2-(5-bromo-2-hydroxyphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 1427035-09-3 4-bromo-2-(3-(hydroxymethyl)imidazo[1,2-a]pyridin-2-yl)phenol 
• 1427035-07-1 2-(5-bromo-2-methoxyphenyl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Synthesis and anti-methicillin-resistant Staphylococcus aureus activity of 5,7-dibromo-2-benzoylbenzofurans alone and in combination with antibiotics

A series of 5,7-dibromo-2-benzoylbenzofurans were synthesized by the Rap–Stoermer condensation of 5,7-dibromosalicylaldehyde with diverse phenacyl bromides and evaluated for in-vitro antibacterial activities against methicillin-sensitive Staphylococcus aureus (MSSA) ATCC 29213, methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, and MRSA ATCC 33591 by agar dilution method. The synergistic effects were determined by using the agar dilution checkerboard assay. The derivatives bearing carboxylic acid functional groups exhibited reasonable activity against MRSA strains with the best MIC = 32 μg/mL (9b, 9d). Moreover, the additive or synergistic interactions against MRSA strains was observed in six combinations (1b + cefuroxime/gentamicin, 1c + ciprofloxacin/gentamicin, 9b + gentamicin, and 9c + ciprofloxacin) with the fractional inhibitory concentration index (FICI) values in the range of 0.375–1.0. Significantly, the MICs of these antibiotics were reduced 2–4-fold. The results of the MTT assay illustrated the low mammalian cell cytotoxicity of these potent compounds.

2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas

Treatment of alkylarenes with N-bromosuccinimide in a mixture of ethyl acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of diethyl carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino- 4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, respectively, in one pot. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions.

Hepatitis C Virus Inhibitors

The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.