676605-99-5

Basic information

• Product Name: (2Z)-3-HYDROXY-2-(4-NITROPHENYL)ACRYLALDEHYDE
• Synonyms: (2Z)-3-HYDROXY-2-(4-NITROPHENYL)ACRYLALDEHYDE
• CAS NO: 676605-99-5
• Molecular Formula: C₉H₇NO₄
• Molecular Weight: 193.16
• Mol File: 676605-99-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 231-233°C
• Appearance: /
• CAS DataBase Reference: (2Z)-3-HYDROXY-2-(4-NITROPHENYL)ACRYLALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-HYDROXY-2-(4-NITROPHENYL)ACRYLALDEHYDE(676605-99-5)
• EPA Substance Registry System: (2Z)-3-HYDROXY-2-(4-NITROPHENYL)ACRYLALDEHYDE(676605-99-5)

Safety Data

• Hazardous Substances Data: 676605-99-5(Hazardous Substances Data)

Usage

Description

(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is a chemical compound with a molecular formula of C9H7NO4. It is a yellow crystalline solid that is commonly used in organic synthesis and as a reagent in chemical reactions. It is also known to have potential applications in pharmaceuticals and agrochemicals due to its unique chemical properties. (2Z)-3-HYDROXY-2-(4-NITROPHENYL)ACRYLALDEHYDE is known to have a high melting point and is insoluble in water, but soluble in organic solvents. Its structure consists of a nitrophenyl group and an aldehyde group, making it an important building block for the synthesis of various organic compounds.

Uses

Used in Organic Synthesis:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the creation of complex molecules.
Used in Chemical Reactions:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a reagent in chemical reactions. Its reactivity with other compounds allows for the formation of new products and the study of reaction mechanisms.
Used in Pharmaceutical Industry:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a starting material for the development of new pharmaceuticals. Its unique chemical properties make it a promising candidate for the synthesis of drugs with novel therapeutic effects.
Used in Agrochemical Industry:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a precursor for the synthesis of agrochemicals. Its potential applications in this industry include the development of new pesticides, herbicides, and other agricultural chemicals.

Upstream product

• 85907-56-8 (Z)-3-(dimethylamino)-2-(4-nitrophenyl)acrylaldehyde 
• 104-03-0 4-nitrobenzeneacetic acid 
• 140-29-4 phenylacetonitrile 
• 555-21-5 4-Nitrophenylacetonitrile 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 676606-01-2 methyl 2,3,4-tri-O-acetyl-(2'-(4''-nitrophenyl)-3'-oxo-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate 
• 676606-04-5 methyl 2,3,4-tri-O-acetyl-(2'-(4''-nitrophenyl)-3'-hydroxy-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate 
• 676606-07-8 methyl 2,3,4-tri-O-acetyl-(2'-(4''-nitrophenyl)-3'-(N-imidocarbonyloxy)-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate 
• 676606-16-9 (2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(E)-3-(4-methoxy-benzylcarbamoyloxy)-2-(4-nitro-phenyl)-propenyloxy]-tetrahydro-pyran-2-carboxylic acid 
• 676606-13-6 methyl [2'-(4''-nitrophenyl)-3'-(4'''-methoxybenzylaminocarbonyloxy)-1'-(E)-propenyloxy]-β-D-glucopyranosiduronate 
• 676606-10-3 methyl 2,3,4-tri-O-acetyl-(2'-(4''-nitrophenyl)-3'-(4'''-methoxybenzylaminocarbonyloxy)-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate 
• 1033049-09-0 C₃₁H₃₀N₃O₄S₂⁽¹⁺⁾*I^(1-) 
• 1033049-11-4 C₄₅H₅₈N₃O₁₀S₂⁽¹⁺⁾*I^(1-) 
• 1033049-08-9 2-[(1E,3Z,5Z)-3-(4-nitrophenyl)-5-(3-propyl-1,3-benzothiazol-2-ylidene)penta-1,3-dienyl]-3-propyl-1,3-benzothiazol-3-ium iodide 
• 1448581-69-8 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid 
• 1448581-70-1 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-7-sulfonic acid 
• 1406224-43-8 4-[1-(pyridin-2-yl)-1H-pyrazol-3-yl]aniline 
• 1448581-65-4 2-[3-(4-nitrophenyl)-1H-pyrazol-1-yl]pyridine 
• 114474-28-1 4-(4-aminophenyl)-1H-pyrazole 

Relevant articles and documents

TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS

Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

Synthesis of novel fluorescent 2-{4-[1-(pyridine-2-yl)-1H-pyrazol-3-yl] phenyl}-2H-naphtho [1,2-d] [1,2,3] triazolyl derivatives and evaluation of their thermal and photophysical properties

Novel 2-{4-[1-(pyridine-2-yl)-1H-pyrazol-3-yl] phenyl}-2H-naphtho [1,2-d] [1,2,3] triazolyl fluorescent derivatives were synthesized from p-nitrophenylacetic acid and 2-hydrazino pyridine through Vilsmeier-Haack and diazotization reactions. Photophysical properties were evaluated, and results show that compounds have good fluorescence quantum yields. Thermal analysis showed that they are reasonably stable. The structures of the compounds were confirmed by FT-IR, 1H NMR, 13C NMR, and mass spectral and elemental analysis.