67685-26-1Relevant articles and documents
Practical synthesis of lespedezol A1
Khupse, Rahul S.,Erhardt, Paul W.
, p. 275 - 277 (2008/12/23)
A practical formal synthesis of lespedezol A1 (1) was accomplished in 33% yield for four steps starting from formation of the substituted chalcone. Of particular note is a useful protocol for reduction of the 2-ene bond in the isoflavone intermediate. A significant improvement in the final ring closure when water was scavenged from the reaction is also noteworthy. The ready availability of lespedezol A1 will provide material for further pharmacological evaluation and for exploration of the pterocarpene nucleus as a potential entry into various 6a-hydroxypterocarpans.
Synthesis of (+/-)-Isomedicarpin, (+/-)-Homopterocarpin and Tuberostan: A Novel Entry of 'Hydrogenative Cyclisation' into Pterocarpans
Krishna Prasad, Awari V.,Kapil, Randhir S.,Popli, Satya P.
, p. 1561 - 1564 (2007/10/02)
An efficient three-step synthesis of the coumestan, tuberostan (1), from the benzyloxyisoflavone (2) is described.The synthesis involves a single-step 'hydrogenative cyclisation' of the isoflavone (2) to the pterocarpan, (+/-)-isomedicarpin (5).
