67727-97-3 Usage
General Description
Alpha-MSH (11-13) acetate salt is a synthetic peptide that consists of the amino acid sequence alanine, threonine, and phenylalanine. It is a derivative of the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH), which is involved in regulating skin pigmentation, inflammation, and appetite. Alpha-MSH (11-13) acetate salt has been studied for its potential role in regulating appetite and metabolism, as well as for its anti-inflammatory and skin-protective properties. It is also being investigated for its potential use in the treatment of obesity, certain skin conditions, and inflammatory diseases. However, further research is needed to fully understand its mechanisms of action and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 67727-97-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,7,2 and 7 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 67727-97:
(7*6)+(6*7)+(5*7)+(4*2)+(3*7)+(2*9)+(1*7)=173
173 % 10 = 3
So 67727-97-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
67727-97-3Relevant articles and documents
Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties
Masman, Marcelo F.,Rodriguez, Ana M.,Svetaz, Laura,Zacchino, Susana A.,Somlai, Csaba,Csizmadia, Imre G.,Penke, Botond,Enriz, Ricardo D.
, p. 7604 - 7614 (2006)
The synthesis, in vitro evaluation, and conformational study of His-Phe-Arg-Trp-NH2 and related derivatives acting as antifungal agents are reported. Among them, His-Phe-Arg-Trp-NH2 and His-Tyr-Arg-Trp-NH2 exhibited antifungal activity against Cryptococcus neoformans. Antifungal activity of these compounds appears to be closely related to the α-MSH effect. A conformational and electronic study allows us to propose a biologically relevant conformation for these tetrapeptides acting as antifungal agents. In addition, these theoretical calculations permit us to determine the minimal structural requirements to produce the antifungal response and may provide a guide for the design of compounds with this biological activity.
