677297-51-7 Usage
Description
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol is a complex organic compound characterized by its unique molecular structure, which features a bisphenol framework with a pteridine ring system. This molecule is known for its potential applications in various fields due to its chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol is used as an active pharmaceutical ingredient for the development of novel therapeutic agents. Its unique chemical structure allows it to interact with specific biological targets, making it a promising candidate for the treatment of various diseases.
Used in Cardiovascular Applications:
In the field of cardiology, 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol is used as a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. This application is significant because it can provide potent cardioprotection, reduce infarct development, and preserve myocardial function, which are crucial for managing and treating heart-related conditions.
Used in Drug Development:
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol is also utilized in drug development as a key building block for the synthesis of new compounds with potential therapeutic applications. Its chemical versatility enables the creation of a wide range of derivatives that can be tailored to target specific diseases or conditions.
Biological Activity
tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2].
references
[1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65.
Check Digit Verification of cas no
The CAS Registry Mumber 677297-51-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,7,2,9 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 677297-51:
(8*6)+(7*7)+(6*7)+(5*2)+(4*9)+(3*7)+(2*5)+(1*1)=217
217 % 10 = 7
So 677297-51-7 is a valid CAS Registry Number.
677297-51-7Relevant articles and documents
Discovery of 3,3′-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction
Palanki, Moorthy S. S.,Dneprovskaia, Elena,Doukas, John,Fine, Richard M.,Hood, John,Kang, Xinshan,Lohse, Dan,Martin, Michael,Noronha, Glenn,Soll, Richard M.,Wrasidlo, Wolfgang,Yee, Shiyin,Zhu, Hong
, p. 4279 - 4294 (2008/02/13)
In studies aimed toward identifying effective and safe inhibitors of kinase signaling cascades that underlie ischemia/reperfusion (I/R) injury, we synthesized a series of pteridines and pyridopyrazines. The design strategy was inspired by the examination
