67739-37-1Relevant articles and documents
Synthesis of 13C-Labeled Pyrazinone Thrombin Inhibitors and Elucidation of Metabolic Activation Pathways
Ho, Jonathan Z.,Braun, Matthew P.,Subramanian, Raju,Gao, Ying-Duo,Dean, Dennis C.,Melillo, David G.
, p. 674 - 681 (2004)
In support of a research program aimed at discovering orally bioavailable thrombin inhibitors, 13C-labeled 3-aminopyrazinone acetamide thrombin inhibitors have been prepared to aid in the structural elucidation of key metabolites during preclin
Direct observation of intramolecular hydrogen bonds in peptide 3 10 helices by 3hJN,C′ scalar couplings
Bellanda, Massimo,Rainaldi, Mario,Broxterman, Quirinus B.,Kaptein, Bernard,Formaggio, Fernando,Crisma, Marco,Mammi, Stefano,Toniolo, Claudio
, p. 3152 - 3155 (2007/10/03)
Differentiating helices: The direct observation of hydrogen bonds by 3hJN,C′ scalar couplings (see picture) is not only possible for α-helix and β-sheet peptides and proteins, but for 310-helical peptides as well. The meth