677746-56-4

Basic information

• Product Name: 6-(4-benzylpiperazin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine
• CAS NO: 677746-56-4
• Molecular Weight: 344.419
• Mol File: 677746-56-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-benzylpiperazin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-benzylpiperazin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine(677746-56-4)
• EPA Substance Registry System: 6-(4-benzylpiperazin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine(677746-56-4)

Safety Data

• Hazardous Substances Data: 677746-56-4(Hazardous Substances Data)

Upstream product

• 52494-53-8 6-chloro-1,2,4-triazolo<3,4-a>phthalazine 
• 2759-28-6 1-phenylmethylpiperazine 
• 4752-10-7 1,4-dichlorophthalazine 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 136918-14-4 phthalimide 

Relevant articles and documents

Synthesis and biological evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties as positive inotropic agents

Two series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties have been synthesized and evaluated for their positive inotropic activity by measuring left atrium stroke volume on isolated rabbit heart preparations. The majority of the derivatives exhibited better in vitro activity than the existing drug, milrinone, and 6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)tetrazolo[5,1-a]phthalazine. 8 m in particular was identified as the most potent with an increased stroke volume of 12.02 ± 0.20% (milrinone: 2.46 ± 0.07%) at a concentration of 3 × 10-5 m. The chronotropic effects of the compounds that exhibited good potency were also evaluated.