6781-65-3

Basic information

• Product Name: Benzoic acid, 4-nitro-,2-benzoylhydrazide
• Synonyms: Hydrazine,1-benzoyl-2-(p-nitrobenzoyl)- (6CI,7CI,8CI); NSC 159531
• CAS NO: 6781-65-3
• Molecular Formula: C14H11 N3 O4
• Molecular Weight: 285.259
• Mol File: 6781-65-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 583.9°Cat760mmHg
• Flash Point: 306.9°C
• Density: 1.359g/cm³
• CAS DataBase Reference: Benzoic acid, 4-nitro-,2-benzoylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-nitro-,2-benzoylhydrazide(6781-65-3)
• EPA Substance Registry System: Benzoic acid, 4-nitro-,2-benzoylhydrazide(6781-65-3)

Safety Data

• Hazardous Substances Data: 6781-65-3(Hazardous Substances Data)

Upstream product

• 619-50-1 4-nitrobenzoic acid methyl ester 
• 65-85-0 benzoic acid 
• 93-89-0 benzoic acid ethyl ester 
• 122-04-3 4-nitro-benzoyl chloride 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 142273-50-5 Z-2-methoxycarbonylmethylene-5-phenyl-2,3-dihydro-3-furanone 
• 85243-74-9 3-benzoyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 861070-90-8 3-(4-nitro-benzoyl)-5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 613-94-5 benzoic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 107518-67-2 N-benzoyl-N'-isopropylidene-N-(4-nitro-benzoyl)-hydrazine 

Downstream Products

• 925102-99-4 4-oxo-4(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenylamino)butanoic acid 
• 610257-94-8 4-fluoro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide 
• 392311-87-4 4-chloro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide 
• 356791-78-1 4-methyl-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide 
• 356792-11-5 4-methoxy-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide 
• 357154-78-0 4-nitro-N-(4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenyl)benzamide 
• 23133-32-6 1-acetoxy-4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-benzene 
• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 53338-48-0 4-(5-phenyl-1,3,4-oxadiazole-2-yl)benzenamine 
• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 1456-68-4 2-(4-nitrophenyl)-5-phenyl-1,3,4-thiadiazole 
• 968-07-0 4-Nitro-azodibenzoyl 
• 1090-82-0 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole 
• 709010-11-7 2-chloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide 

Relevant articles and documents

One-pot synthesis of 1,3,4-thiadiazoles using Vilsmeier reagent as a versatile cyclodehydration agent

A simple and efficient synthetic method for the one-pot synthesis of 1,3,4-thiadiazoles utilizing Vilsmeier reagent was developed. In this method carboxylic acids and hydrazine were converted to 1,3,4-thiadiazoles in the presence of Vilsmeier reagent and Lawesson's reagent. The influence of the thionation reagent, solvent, temperature and time, in this reaction was discussed. The developed methodology for 1,3,4-thiadiazole synthesis has the advantage of simplicity, ambient reaction conditions, easy purification and good to excellent yield of products.

Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1,2,4-oxadiazole 3 (metHb% = 61.0 ± 3.6) and 1,3,4-oxadiazole 10 (metHb% = 52.4 ± 0.9) demonstrating the greatest activity. Of the 5 candidates (compounds 3, 10, 11, 13 and 23) evaluated in vivo, failure to induce a lethal end-point at doses of 120 mg/kg was observed in all cases. Inadequate metabolic stability, particularly towards hepatic enzymes such as the CYPs, was postulated as one reason for their failure.

Near-infrared-absorbing organic electrochromic materials

The invention provides generally a new type of organic electrochromic Near Infrared (NIR)-active materials capable of absorbing and attenuating the light in the NIR region around 1550 nm and forming thin films on electrodes for variable optical attenuator