6784-46-9

Basic information

• Product Name: farnesylamine
• Synonyms: farnesylamine;3,7,11-Trimethyl-2,6,10-dodecatrien-1-amine
• CAS NO: 6784-46-9
• Molecular Formula: C₁₅H₂₇N
• Molecular Weight: 221.3816
• Mol File: 6784-46-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 318.5°Cat760mmHg
• Flash Point: 137.2°C
• Appearance: /
• Density: 0.851g/cm³
• Vapor Pressure: 0.00036mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: farnesylamine(CAS DataBase Reference)
• NIST Chemistry Reference: farnesylamine(6784-46-9)
• EPA Substance Registry System: farnesylamine(6784-46-9)

Safety Data

• Hazardous Substances Data: 6784-46-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 23, p. 535, 1993 DOI: 10.1080/00397919308009810

InChI:InChI=1/C15H27N/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11H,5-6,8,10,12,16H2,1-4H3/b14-9+,15-11+

Upstream product

• 4602-84-0 farnesol 
• 148162-66-7 N-farnesyltrifluoroacetamide 
• 123022-37-7 N-farnesylphtalimide 
• 176650-39-8 4-Methyl-N-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzenesulfonamide 
• 106-28-5 Farnesol 
• 24163-93-7 farnesyl bromide 
• 148162-64-5 (2E,6E)-1-azido-3,7,11-trimethyldodeca-2,6,10-triene 

Downstream Products

• 181703-94-6 (S)-2-Benzyloxycarbonylamino-3-[benzyloxycarbonyl-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-amino]-propionic acid 
• 147315-58-0 N-homogeranyl-N-methyl-N'-farnesylformamidine 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

Provided herein are lipidated glycopeptide compounds of formula (I); or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof. R1 is a lipid, R2 is -H or a lipid, and R3 and R4 are as defined herein. These compounds have antibiotic activity. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may also be used in the treatment of bacterial infection.

NISIN-BASED COMPOUNDS AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS

The invention relates to new antimicrobial compounds derived from nisin. In particular, the compounds are based on the unsubstituted nisin [1-12] structure, wherein said compounds have an antimicrobial activity exceeding the activity of the unsubstituted nisin [1-12] structure.

Synthesis of cyclopentenimines from N-allyl ynamides via a tandem aza-Claisen rearrangement-carbocyclization sequence

We describe here details of our investigations into Pd-catalyzed and thermal aza-Claisen-carbocyclizations of N-allyl ynamides to prepare a variety of α,β-unsaturated cyclopentenimines. The nature of the ynamide electron-withdrawing group and β-substituent plays critical roles in the success of this tandem cascade. With N-sulfonyl ynamides, the use of palladium catalysis is required, as facile 1,3-sulfonyl shifts dominate under thermal conditions. However, since no analogous 1,3-phosphoryl shift is operational, N-phosphoryl ynamides could be used to prepare similar cyclopentenimines under thermal conditions through zwitter ionic intermediates that undergo N-promoted H-shifts. Alternatively, by employing ynamides bearing tethered carbon nucleophiles, the zwitter ionic intermediates could be intercepted, giving rise rapidly to more complex fused bi- and tricyclic scaffolds.