6784-61-8Relevant articles and documents
Theoretical and model studies on the chemoselectivity of a Grignard reagent's reaction with a combined aminonitrile-oxazolidine system
Aitken, David J,Beaufort, Virginie,Chalard, Pierre,Cladière, Jean-Luc,Dufour, Monique,Pereira, Elisabeth,Théry, Vincent
, p. 5933 - 5940 (2002)
Semi-empirical quantum chemical studies using PM3 suggest that the preferred reaction between a Grignard reagent and a combined aminonitrile-oxazolidine system involves initial formation of a Lewis acid-base complex between magnesium and the central nitrogen atom, followed by preferred reaction with the aminonitrile function; model studies confirm that this reaction proceeds by addition rather than substitution.
Preparation method of N-acetonyl amine compound
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Paragraph 0046, (2016/10/09)
The invention discloses a preparation method of an N-acetonyl amine compound. The method comprises the following steps that an amine compound and glycerin are used as reaction raw materials, and in the presence of a composite catalyst and an alkali addition agent, in reaction mediums and at the reaction temperature of 80-180 DEG C, a reaction is performed for 2-48 hours in a sealed reactor so that the N-acetonyl amine compound is obtained. The method disclosed by the invention is simple, reaction conditions are mild, target products can be obtained at a low cost and at a high yield, and the used catalyst has high catalytic activity and is easy to separate and repeatedly use in a reaction system; besides, the whole process is environment-friendly, and the utilization of by-products namely the glycerin of biologic diesel oil is promoted.
Highly chemoselective α-diazo carbonyl insertion reactions into N-H and S-H bonds catalysed by [RuCl(η5-C5H5)(PPh3)2]
Del Zotto, Alessandro,Baratta, Walter,Rigo, Pierluigi
, p. 3079 - 3082 (2007/10/03)
Complex [RuCl(η5-C5H5)(PPh3)2], in chloroform at 60 deg C, catalyses the chemoselective insertion of α-diazo carbonyl compounds into N-H and S-H bonds to afford α-keto-amines and α-keto-thioethers.