67862-28-6

Basic information

• Product Name: 4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one
• Synonyms: 4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one
• CAS NO: 67862-28-6
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.2414
• Mol File: 67862-28-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 438.4°Cat760mmHg
• Flash Point: 218.9°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 1.84E-08mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one(67862-28-6)
• EPA Substance Registry System: 4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one(67862-28-6)

Safety Data

• Hazardous Substances Data: 67862-28-6(Hazardous Substances Data)

Usage

Description

4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one is a chemical compound that belongs to the naphthyridine class of compounds. It is a derivative of 1,8-naphthyridin-2(1H)-one and contains a hydroxyl group and a phenyl group. 4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one has potential pharmaceutical applications due to its structural and biological properties.

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one is used as a potential pharmaceutical candidate for various applications due to its structural and biological properties. It may have antioxidant, antimicrobial, or anticancer properties, making it a promising compound for drug development and medicinal chemistry.
Used in Drug Development:
4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one is used as a compound in drug development, where its potential pharmaceutical applications are being explored. Further research is needed to fully understand and harness the potential benefits and applications of this compound in the development of new drugs.
Used in Medicinal Chemistry:
4-Hydroxy-3-phenyl-1,8-naphthyridin-2(1H)-one is used in medicinal chemistry for the study of its structural and biological properties. Its potential antioxidant, antimicrobial, and anticancer properties make it a valuable compound for research and development in the field of medicinal chemistry.

InChI:InChI=1/C14H10N2O2/c17-12-10-7-4-8-15-13(10)16-14(18)11(12)9-5-2-1-3-6-9/h1-8H,(H2,15,16,17,18)

Upstream product

• 372951-31-0 ethyl 2-amido-(N-phenylacetyl)nicotinate 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists

A series of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [3H]5,7-dicholorokynurenic acid ([3H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (13i) is the most potent antagonist, having an IC50 value of 110 nM in [3H]DCKA binding and a Kb of 11 nM in the electrophysiology assay. Compound 13i is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED50 = 2.3 mg/kg, IP).