678991-36-1Relevant articles and documents
Amide α,β-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide
Chen, Yifeng,Turlik, Aneta,Newhouse, Timothy R.
supporting information, p. 1166 - 1169 (2016/02/18)
A practical and direct method for the α,β-dehydrogenation of amides is reported using allyl-palladium catalysis. Critical to the success of this process was the synthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan). The reaction conditions tolerate a wide variety of substrates, including those with acidic heteroatom nucleophiles.
Asymmetric Synthesis of β-Amino Esters by Aza-Michael Reaction of α,β-Unsaturated Amides Using (S,S)-(+)-Pseudoephedrine as Chiral Auxiliary
Etxebarria, Juan,Vicario, Jose L.,Badia, Dolores,Carrillo, Luisa
, p. 2588 - 2590 (2007/10/03)
Chiral nonracemic β-amino esters were prepared in good yields and enantioselectivities using the diastereo-selective conjugate addition of nitrogen nucleophiles to α,β-unsaturated amides derived from (S,S)-(+)-pseudoephedrine as the key step. In this way, several β-amino amide adducts were prepared using different conjugate acceptors and two different lithium benzylamides as nucleophiles. These adducts were easily converted in only one step, into the final, highly enantioenriched β-amino esters.
