67979-25-3 Usage
Description
Aurantio-obtusin is an anthraquinone compound originally isolated from Cassia seeds, characterized by its diverse biological activities. It is a trihydroxyanthraquinone with methoxy groups at positions 2 and 8, and a methyl group at position 6. Aurantio-obtusin has demonstrated the ability to inhibit rat lens aldose reductase (RLAR) in vitro, activate the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner, and exhibit larvicidal properties against A. gambiae mosquitoes.
Uses
1. Used in Herbal Remedies:
Aurantio-obtusin is used as a component in herbal remedies for its potential effects on blood platelet aggregation and lowering blood lipid count.
2. Used in Pharmaceutical Applications:
Aurantio-obtusin is used as an inhibitor for rat lens aldose reductase (RLAR) in vitro, with an IC50 value of 13.6 μM, making it a potential candidate for the development of pharmaceuticals targeting this enzyme.
3. Used in Activating Aryl Hydrocarbon Receptor (AhR):
Aurantio-obtusin is used as an activator of the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner, which may have implications for various biological processes and therapeutic applications.
4. Used in Antiplatelet and Vasorelaxation Applications:
Aurantio-obtusin is used as an inhibitor of rat platelet aggregation induced by arachidonic acid, ADP, and collagen. Additionally, it is used to induce vasorelaxation in isolated precontracted rat mesenteric artery rings, which can be inhibited by the PI3K inhibitor LY290042 or by inhibiting endothelial nitric oxide synthase (eNOS). These properties suggest potential applications in the treatment of cardiovascular diseases.
5. Used in Insect Control:
Aurantio-obtusin is used as a larvicidal agent against A. gambiae mosquitoes, with an LD50 value of 10 ppm, indicating its potential use in insect control and vector-borne disease management.
Check Digit Verification of cas no
The CAS Registry Mumber 67979-25-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,7 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 67979-25:
(7*6)+(6*7)+(5*9)+(4*7)+(3*9)+(2*2)+(1*5)=193
193 % 10 = 3
So 67979-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H14O7/c1-6-4-7-11(17(24-3)12(6)19)14(21)10-8(13(7)20)5-9(18)16(23-2)15(10)22/h4-5,18-19,22H,1-3H3
67979-25-3Relevant articles and documents
SYNTHESIS OF SPECIFICALLY O-ALKYLATED ANTHRAQUINONES BY CYCLOADDITION
Cameron, Donald W.,Feutrill, Geoffrey I.,Gamble, Glenn B.,Stavrakis, John
, p. 4999 - 5002 (2007/10/02)
Cycloadducts from naphthoquinonoid dienophiles and 1-methoxy-1-trimethylsilyloxy butadienes undergo controlled aromatisation to form chiefly α-hydroxy- or α-methoxy-anthraquinones; this has led to synthesis of several natural O-methyl polyoxyanthraquinones.
