6801-22-5

Basic information

• Product Name: melinonine F
• Synonyms: melinonine F;1,2-Dimethyl-9H-pyrido[3,4-b]indol-2-ium;2[N]-Methylharmanium;2-Methylharman;9H-Pyrido(3,4-B)indolium, 1,2-dimethyl-
• CAS NO: 6801-22-5
• Molecular Formula: C13H13 N2
• Molecular Weight: 0
• Mol File: 6801-22-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: melinonine F(CAS DataBase Reference)
• NIST Chemistry Reference: melinonine F(6801-22-5)
• EPA Substance Registry System: melinonine F(6801-22-5)

Safety Data

• Hazardous Substances Data: 6801-22-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2/c1-9-13-11(7-8-15(9)2)10-5-3-4-6-12(10)14-13/h3-8H,1-2H3/p+1

Upstream product

• 486-84-0 harmane 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

Exploiting the polypharmacology of ?-carbolines to disrupt o. volvulus molting

Onchocerciasis is an infection caused by the filarial worm Onchocerca volvulus, which can eventually result in blindness. The lack of an effective macrofilaricide and the possible development of ivermectin-resistant strains of O. volvulus necessitate the need for alternative treatment strategies. We have shown that targeting the L3-stage-specific chitinase OvCHT1 impairs the shedding of the filarial cuticle. In our continued efforts to discover OvCHT1 inhibitors, we identified the β-carboline alkaloid scaffolding as a chitinase inhibitor that is capable of penetrating the worm cuticle. Herein, we disclose the rich polypharmacology of the β-carboline class of compounds as an approach to abrogate the molting of the parasite and thus the initiation of infection in the human host.