68014-57-3

Basic information

• Product Name: N-(2-Methylphenyl)-2,6-dimethylaniline
• Synonyms: 1',2,3'-Trimethyl[1,2'-iminobisbenzene];2,6-Dimethyl-N-(2-methylphenyl)benzenamine;N-(2-Methylphenyl)-2,6-dimethylaniline;2,6-dimethyl-N-o-tolylaniline
• CAS NO: 68014-57-3
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.3
• Mol File: 68014-57-3.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-Methylphenyl)-2,6-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methylphenyl)-2,6-dimethylaniline(68014-57-3)
• EPA Substance Registry System: N-(2-Methylphenyl)-2,6-dimethylaniline(68014-57-3)

Safety Data

• Hazardous Substances Data: 68014-57-3(Hazardous Substances Data)

Usage

General Description

N-(2-Methylphenyl)-2,6-dimethylaniline is a chemical compound with the molecular formula C15H17N. It is an organic compound classified as an aniline derivative, which is commonly used as a raw material in the production of dyes and pigments. This chemical is a pale yellow crystalline solid with a faint odor, and it is insoluble in water but soluble in organic solvents. N-(2-Methylphenyl)-2,6-dimethylaniline is a potentially hazardous substance, and exposure to it can cause skin and eye irritation, as well as harmful effects on the central nervous system. Therefore, proper safety precautions should be taken when handling this chemical.

Upstream product

• 95-49-8 2-methylchlorobenzene 
• 87-62-7 2,6-dimethylaniline 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 95-53-4 o-toluidine 
• 95-46-5 2-methylphenyl bromide 
• 615-37-2 ortho-methylphenyl iodide 
• 88-05-1 2,4,6-trimethylaniline 

Relevant articles and documents

N-Heterocyclic Carbene Palladium(II) Amine Complexes: The Role of Primary Aryl- or Alkylamine Binding and Applications in the Buchwald-Hartwig Amination Reaction

N-heterocyclic carbene-palladium(II) amine complexes bearing primary aryl- or alkylamines were synthesized. The prepared complexes were characterized by single crystal X-ray diffraction as well as NMR spectroscopy. These complexes exhibited good catalytic activities for the Buchwald-Hartwig amination reaction of aryl chlorides to afford arylated anilines under mild conditions. All reactions were carried out in air and all starting materials were used as supplied without purification. 21 expected coupling products were obtained in moderate to high yields under optimum conditions.

N-Heterocyclic carbene-palladacyclic complexes: synthesis, characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01 mol%).

Organonickel complexes encumbering bis-imidazolylidene carbene ligands: Synthesis, X-ray structure and catalytic insights on Buchwald-Hartwig amination reactions

New four coordinated homoleptic bis(diimidazolylidene)nickel(II) complexes (C1 & C2) were synthesized and characterized by elemental analysis, NMR (1H and13C) as well as ESI-Mass spectrometry. The molecular structure of the complex C1 was identified by means of single-crystal X-ray diffraction analysis, which revealed that the complexes possess a distorted square planar geometry with chelating bis(diimidazolylidene) NHC ligands and two non coordinating bromide counter ions in tetradentate C4fashion. A survey of their catalytic activity in Buchwald?Hartwig amination has been performed. The newly synthesized complexes also catalyzed the amination of aryl chlorides in the presence of KOtBu. Various aryl chlorides and amines can react smoothly to give the corresponding aminated products in moderate to high yields. The scope of the reaction encompasses electronically varied aryl chlorides and nitrogen-containing heteroaryl chlorides, including pyridine and quinoline derivatives. Both secondary and primary amines are well tolerated under the optimal reaction conditions.