6804-07-5 Usage
Description
Carbadox is a quinoxaline-di-N-oxide antibiotic that possesses unique properties and applications in various fields. It is known for its ability to suppress aldosterone production, study the spread of shiga toxin-producing Escherichia coli (STEC) strains, and compare different antimicrobial activities. Carbadox's mode of action involves intercalation and induction of mutations in the bacterial genome, making it an effective agent against certain bacteria.
Uses
Used in Veterinary Medicine:
Carbadox is used as a growth promoter and therapeutic agent for swine. It is incorporated into feed to prevent dysentery and improve feed efficiency in pigs. The antibiotic properties of Carbadox help control bacterial infections and promote overall health and growth in the animals.
Used in Pharmaceutical Research:
Carbadox is utilized in the study of aldosterone production, a hormone that plays a crucial role in regulating blood pressure and electrolyte balance. By suppressing aldosterone production, researchers can gain insights into the mechanisms of hypertension and develop potential treatments for related conditions.
Used in Microbiology:
Carbadox is employed to study the spread of shiga toxin-producing Escherichia coli (STEC) strains. These strains are responsible for causing severe foodborne illnesses, and understanding their behavior can help in developing strategies to control and prevent their spread.
Used in Antimicrobial Activity Comparison:
Carbadox is used to compare different antimicrobial activities against various bacterial strains. This comparison helps in identifying the most effective antibiotics for specific infections and contributes to the development of new antimicrobial agents.
Originator
Carbadox,Agrimex
Manufacturing Process
A solution of methylcarbazate (48.0 mg) in methanol (250 ml) is added all at
once at room temperature to a well stirred solution of 2-formylquinoxaline-
1,4-dioxide (100 g) in methanol (2.5 liters). Two drops of concentrated
hydrochloric acid are added. The mixture is stirred for 3 hours then filtered to remove the yellow crystalline product. The crystals of (2-
quinoxalinylmethylene)hydrazinecarboxylic acid methyl ester are washed with
methanol then air dried; M.P. 234.5-236°C (dec.). Yield=121.8 g. The product
is purified by refluxing in chloroform for 2 hours, followed by filtration and air
drying; M.P. 239.5-240°C (dec.).The ultraviolet absorption spectrum (water) exhibits maxima at 236, 251,
303, 366 and 373 nm with extinction coefficients of 11,000, 10,900, 36,400,
16,100 and 16,200, respectively.
Therapeutic Function
Antibacterial
Biochem/physiol Actions
Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency. It inhibits bacteria by intercalation and induction of mutations in bacterial genome.
Safety Profile
Moderately toxic by
ingestion. Questionable carcinogen with
experimental carcinogenic effects. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of Nox.
Check Digit Verification of cas no
The CAS Registry Mumber 6804-07-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,0 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6804-07:
(6*6)+(5*8)+(4*0)+(3*4)+(2*0)+(1*7)=95
95 % 10 = 5
So 6804-07-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+
6804-07-5Relevant articles and documents
Process for formulating a synthetic drug for use in animal feed, and resulting formulation
-
, (2008/06/13)
A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.