68065-11-2

Basic information

• Product Name: 4-(3-BROMO-PROPOXY)-PHENOL
• Synonyms: 4-(3-BROMO-PROPOXY)-PHENOL;4-(3-broMopropoxy)-
• CAS NO: 68065-11-2
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.09
• Product Categories: API intermediates
• Mol File: 68065-11-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 345.2°C at 760 mmHg
• Flash Point: 162.6°C
• Appearance: /
• Density: 1.462g/cm³
• Vapor Pressure: 3.14E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: 10.27±0.15(Predicted)
• CAS DataBase Reference: 4-(3-BROMO-PROPOXY)-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-BROMO-PROPOXY)-PHENOL(68065-11-2)
• EPA Substance Registry System: 4-(3-BROMO-PROPOXY)-PHENOL(68065-11-2)

Safety Data

• Hazardous Substances Data: 68065-11-2(Hazardous Substances Data)

Usage

General Description

4-(3-Bromo-propoxy)-phenol is a chemical compound with the chemical formula C9H11BrO2. It is a derivative of phenol, featuring a bromine atom and a propoxy (CH3CH2CH2O) group attached to the phenol ring. The compound is used primarily as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes. It can also be used as a reagent in organic synthesis and as a building block in the preparation of other organic compounds. Although it is not widely studied for biological or toxicological effects, it is important to handle this compound with caution and use proper personal protective equipment due to its potential hazards.

InChI:InChI=1/C9H11BrO2/c10-6-1-7-12-9-4-2-8(11)3-5-9/h2-5,11H,1,6-7H2

Upstream product

• 80199-92-4 1-benzyloxy-4-(3-bromopropoxy)benzene 
• 103-16-2 4-Benzyloxyphenol 
• 123-31-9 hydroquinone 
• 109-64-8 1,3-dibromo-propane 
• 108534-47-0 4-(tert-butyldimethylsilyloxy)phenol 

Downstream Products

• 910032-57-4 [4-(3-bromo-propoxy)-phenoxy]-acetic acid methyl ester 
• 841200-73-5 1-[3-(4-hydroxy-phenoxy)-propyl]-4-phenyl-piperidin-4-ol hydrogen bromide 
• 192872-86-9 2-Benzyl-1-(3-(4-hydroxyphenoxy)propyl)piperidine Hydrochloride 
• 1431659-37-8 4-(3-(ethyl(phenyl)amino)propoxy)phenol 

Relevant articles and documents

Ionic-liquid supported rapid synthesis of an: N -glycan core pentasaccharide on a 10 g scale

A new and efficient Ionic Liquid-Supported Oligosaccharide Synthesis (ILSOS) strategy for an N-linked core pentasaccharide on a 10 g scale is reported. This new ILSOS includes a new spacer for an IL support, a new tagging strategy, and fast, efficient and orthogonal removal of the ionic-liquid support, producing the N-linked core pentasaccharide with direct applicability potential in a short time, with high yield and on a large gram scale.

Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia

This study explores the possible use of reactive oxygen-activated DNA modifying agents against acute myeloid leukemia (AML). A key amine on the lead agent was investigated via cytotoxicity assays and was found necessary for potency. The two best compounds were screened via the NCI-60 cell panel. These two compounds had potency between 200 and 800 nM against many of the leukemia cancer cell types. Subsequent experiments explored activity against a transformed AML model that mimics the molecular signatures identified in primary AML patient samples. A lead compound had an IC50 of 760 nM against this AML cell line as well as a therapeutic index of 7.7 ± 3 between the transformed AML model cell line and non-cancerous human CD34+ blood stem/progenitor cells (UCB). The selectivity was much greater than the mainstays of AML treatment: doxorubicin and cytarabine. This manuscript demonstrates that this novel type of agent may be useful against AML.

LTA4H modulators and uses thereof

Leukotriene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation.