6814-72-8

Basic information

• Product Name: 4-(3-ethoxy-2-methyl-3-oxopropyl)morpholin-4-ium
• CAS NO: 6814-72-8
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 202.2702
• Mol File: 6814-72-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 279.3°C at 760 mmHg
• Flash Point: 122.7°C
• Vapor Pressure: 0.00405mmHg at 25°C
• CAS DataBase Reference: 4-(3-ethoxy-2-methyl-3-oxopropyl)morpholin-4-ium(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-ethoxy-2-methyl-3-oxopropyl)morpholin-4-ium(6814-72-8)
• EPA Substance Registry System: 4-(3-ethoxy-2-methyl-3-oxopropyl)morpholin-4-ium(6814-72-8)

Safety Data

• Hazardous Substances Data: 6814-72-8(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 18470-33-2 Nortropacocaine 
• 98-88-4 benzoyl chloride 
• 135-97-7 pseudotropine 
• 537-26-8 tropacocain 

Relevant articles and documents

Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors

Twenty esters of 3α- and 3β-hydroxy(nor)tropanes and two amides of 3α-aminotropane were prepared with substituted benzoic acids. These (nor)tropeines inhibited [3H]strychnine binding to glycine receptors in synaptosomal membranes of rat spinal cord. A ternary allosteric model was applied to determine the dissociation constants (KA) of the tropeines having strong negative cooperativities with [3H]strychnine binding (α > 10). KA values about 10 nM are well below those of known allosteric agents. Low concentrations (0.1KA) of the (nor)tropeines potentiated the displacing effects of glycine. Positive cooperativity with glycine (β1) decreased with the increase in concentration and binding affinity of tropeines. Displacing potencies were also measured for [3H]granisetron binding to 5-HT3 type serotonin receptors of rat cerebral cortex. Selectivities to glycine receptors versus 5-HT3 receptors varied within 4 orders of magnitude. Nortropeines might serve as a lead to high-affinity selective allosteric modulators of glycine receptors.