681828-95-5

Basic information

• Product Name: 3(2H)-Pyridazinone,5-acetyl-4-amino-2-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]propyl]-6-phenyl-
• CAS NO: 681828-95-5
• Molecular Formula: C27H33N5O3
• Molecular Weight: 475.591
• Mol File: 681828-95-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone,5-acetyl-4-amino-2-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]propyl]-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone,5-acetyl-4-amino-2-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]propyl]-6-phenyl-(681828-95-5)
• EPA Substance Registry System: 3(2H)-Pyridazinone,5-acetyl-4-amino-2-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]propyl]-6-phenyl-(681828-95-5)

Safety Data

• Hazardous Substances Data: 681828-95-5(Hazardous Substances Data)

Upstream product

• 17335-08-9 5-acetyl-4-aminopyridazinone 

Downstream Products

• 681829-05-0 4-amino-2-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propyl}-5-(1-hydroxy-ethyl)-6-phenyl-2H-pyridazin-3-one 

Relevant articles and documents

4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: Synthesis and antinociceptive activity

A series of 4-amino-3(2H)-pyridazinones substituted at position 2 with arylpiperazinylalkyl groups and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Preliminary SARs studies were performed. Several of the novel compounds dosed at 100 mg/kg s.c. significantly reduced the number of writhes induced by the noxious stimulus. Compound 12e showed 100% inhibition of writhes and was able to protect all the treated animals from the effect of the chemical stimulus. Subsequent dose-response studies revealed 12e to be almost 40-fold more potent than the structurally related Emorfazone.