68208-25-3

Basic information

• Product Name: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL
• Synonyms: RARECHEM AK ML 0439;3-AMINO-3-(3-CHLOROPHENYL)-1-PROPANOL;3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL;DL-BETA-(3-CHLOROPHENYL)ALANINOL;DL--(3-Chlorophenyl)alaninol;3-(3-CHLOROPHENYL)-DL-BETA-ALANINOL ;REF DUPL: DL-beta-(3-chlorophenyl)alaninol;Benzenepropanol, .gamma.-amino-3-chloro-
• CAS NO: 68208-25-3
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.65
• Mol File: 68208-25-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 327.9 °C at 760 mmHg
• Flash Point: 152.1 °C
• Appearance: /
• Density: 1.216 g/cm³
• Vapor Pressure: 7.93E-05mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL(68208-25-3)
• EPA Substance Registry System: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL(68208-25-3)

Safety Data

• Hazardous Substances Data: 68208-25-3(Hazardous Substances Data)

Usage

General Description

3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL is a chemical compound with the molecular formula C9H12ClNO. It is a white to off-white crystalline solid with a molecular weight of 187.65 g/mol. 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL belongs to the class of organic compounds known as phenylpropanes, which are compounds containing a phenylpropane moiety. It is commonly used in the synthesis of pharmaceuticals and other organic compounds. This chemical has important biological activities, including antimicrobial and anti-inflammatory properties, making it a valuable compound for various industrial and research applications.

InChI:InChI=1/C9H12ClNO/c10-8-3-1-2-7(6-8)9(11)4-5-12/h1-3,6,9,12H,4-5,11H2

Upstream product

• 68208-21-9 3-amino-3-(3-chloro-phenyl)-propionic acid 
• 587-04-2 m-Chlorobenzaldehyde 

Downstream Products

• 677006-15-4 acetic acid 3-acetylamino-3-(3-chloro-phenyl)-propyl ester 
• 677006-31-4 4-(3-chloro-phenyl)-2-methyl-5,6-dihydro-4H-[1,3]thiazine 
• 677006-26-7 N-[1-(3-chloro-phenyl)-3-hydroxy-propyl]-thioacetamide 
• 677006-20-1 acetic acid 3-(3-chloro-phenyl)-3-thioacetylamino-propyl ester 

Relevant articles and documents

BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR

The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.