6821-01-8

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[4-(1-piperidinyl)butyl]-
• CAS NO: 6821-01-8
• Molecular Formula: C17H22N2O2
• Molecular Weight: 286.374
• Mol File: 6821-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[4-(1-piperidinyl)butyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[4-(1-piperidinyl)butyl]-(6821-01-8)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[4-(1-piperidinyl)butyl]-(6821-01-8)

Safety Data

• Hazardous Substances Data: 6821-01-8(Hazardous Substances Data)

Usage

General Description

The chemical "1H-Isoindole-1,3(2H)-dione, 2-[4-(1-piperidinyl)butyl]-" is a compound with the molecular formula C17H23NO2. It consists of an isoindole-1,3-dione core with a butyl chain substituted with a piperidine ring. 1H-Isoindole-1,3(2H)-dione, 2-[4-(1-piperidinyl)butyl]- is known for its pharmacological activities and has been studied for its potential as a therapeutic agent. Its structural features suggest that it could potentially interact with biological targets in the body, and it may have applications in various fields such as medicine and pharmacology. The specific properties and potential uses of this compound would depend on further research and testing.

Upstream product

• 7743-29-5 [3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-triphenyl-phosphonium bromide 

Downstream Products

• 874450-03-0 1-(4-bromophenyl)-3-(4-piperidin-1-ylbutyl)urea 
• 848861-40-5 4-piperidinobutylcarbamic acid benzyl ester 
• 42152-99-8 2-(4-chlorobutyl)isoindoline-1,3-dione 

Relevant articles and documents

Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl] isothioureas: High affinity and human/rat species-selective histamine H 3 receptor antagonists

S-Alkyl-N-alkylisothiourea compounds containing various cyclic amines were synthesized in the search for novel nonimidazole histamine H3 receptor (H3R) antagonists. Among them, four N-alkyl S-[3-(piperidin-1-yl)propyl]isothioureas 18, 19, 22, and 23 were found to exhibit potent and selective H3R antagonistic activities against in vitro human H3R, but were inactive against in vitro human H 4R. Furthermore, three alkyl homologs 18-20 showed inactivity for histamine release in in vivo rat brain microdialysis, suggesting differences in antagonist affinities between species. In addition, in silico docking studies of N-[4-(4-chlorophenyl)butyl]-S-[3-piperidin-1-yl)propyl]isothiourea 19 and a shorter homolog 17 with human/rat H3Rs revealed that structural differences between the antagonist-docking cavities of rat and human H 3Rs were likely caused by the Ala122/Val122 mutation.