68217-95-8

Basic information

• Product Name: 5,7-dihydroxy-4-methyl-3-phenyl-2H-chromen-2-one
• Synonyms: 5,7-dihydroxy-4-methyl-3-phenyl-2H-chromen-2-one
• CAS NO: 68217-95-8
• Molecular Weight: 268.269
• Mol File: 68217-95-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5,7-dihydroxy-4-methyl-3-phenyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dihydroxy-4-methyl-3-phenyl-2H-chromen-2-one(68217-95-8)
• EPA Substance Registry System: 5,7-dihydroxy-4-methyl-3-phenyl-2H-chromen-2-one(68217-95-8)

Safety Data

• Hazardous Substances Data: 68217-95-8(Hazardous Substances Data)

Upstream product

• 114-70-5 sodium phenylacetate 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 103-80-0 phenylacetyl chloride 
• 108-73-6 3,5-dihydroxyphenol 
• 5413-05-8 ethyl 2-phenylacetoacetate 

Downstream Products

• 68218-04-2 5,7-dimethoxy-4-methyl-3-phenylcoumarin 

Relevant articles and documents

Discovery and optimization of novel 3-piperazinylcoumarin antagonist Of chemokine-like factor 1 with oral antiasthma activity in mice

Chemokine-like factor 1 (CKLF1) is a novel functional cytokine that acts through its receptor CC chemokine receptor 4 (CCR4). Activation of CCR4 by CKLF1 plays an important role in diseases such as asthma and multiple sclerosis. This article describes a cell-based screening assay using an FITC-labeled CCR4 agonist (CKLF1-C27), a CKLF1 peptide fragment. Screening of our in-stock smallmolecule library identified a 3-piperazinylcoumarin analogue 1 (IC 50 = 4.36 × 10-6 M) that led to the discovery of orally active compound, 41 (IC50 = 2.12 × 10-8 M) through systematic optimization. Compound 41 blocked the calcium mobilization and Chemotaxis induced, by CKLF1-C27 and reduced the asthmatic pathologic changes in lung tissue of human CKLF1-transfected mice. Further studies indicated that compound 41 ameliorated pathological changes via inhibition of the NF-κB signal pathway.

A Novel and Conveneint Synthesis of 3-Phenylcoumarins

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