68263-23-0

Basic information

• Product Name: Isoquinoline, 1,2,3,4-tetrahydro-1-(2-phenylethyl)-
• CAS NO: 68263-23-0
• Molecular Formula: C17H19N
• Molecular Weight: 237.345
• Mol File: 68263-23-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1,2,3,4-tetrahydro-1-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,2,3,4-tetrahydro-1-(2-phenylethyl)-(68263-23-0)
• EPA Substance Registry System: Isoquinoline, 1,2,3,4-tetrahydro-1-(2-phenylethyl)-(68263-23-0)

Safety Data

• Hazardous Substances Data: 68263-23-0(Hazardous Substances Data)

Upstream product

• 1428485-05-5 benzyl 1-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 78317-83-6 2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 536-74-3 phenylacetylene 
• 1337924-99-8 C₂₄H₂₄N₂O 
• 1337924-60-3 C₂₄H₂₀N₂O 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 81045-39-8 5,8-dibromoisoquinoline 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 90482-02-3 (S)-valinol-tert-butyl ether formamidine of 1,2,3,4 tetrahydro-isoquinoline 
• 103-63-9 1-phenyl-2-bromoethane 
• 79271-27-5 2-iodo-N-(2-phenylethyl)benzamide 
• 93816-58-1 1-phenethyl-3,4-dihydroisoquinoline 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 

Relevant articles and documents

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Asymmetric Aerobic Oxidative Cross-Coupling of Tetrahydroisoquinolines with Alkynes

An efficient asymmetric aerobic oxidation of tetrahydroisoquinolines with terminal alkynes was realized under mild reaction conditions using O2 as the sole oxidant. A chiral N,N′-dioxide/zinc(II)/iron(II) bimetallic cooperative catalytic system

Catalytic asymmetric alkynylation of C1-substituted C,N-cyclic azomethine imines by CuI/chiral bronsted acid co-catalyst

It all adds up: The title reaction was developed for the synthesis of chiral tetrahydroisoquinoline derivatives with a tetrasubstituted carbon center at the C1-position (see scheme, Bz=benzoyl, pybox=2,6-bis(2-oxazolinyl)pyridine) . The reaction was facilitated effectively by the co-catalyst system composed of copper(I)/Ph-pybox and an axially chiral dicarboxylic acid.