682773-53-1

Basic information

• Product Name: Piperazine, 1-phenyl-4-(2-pyridinyl)-
• CAS NO: 682773-53-1
• Molecular Formula: C15H17N3
• Molecular Weight: 239.32
• Mol File: 682773-53-1.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-phenyl-4-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-phenyl-4-(2-pyridinyl)-(682773-53-1)
• EPA Substance Registry System: Piperazine, 1-phenyl-4-(2-pyridinyl)-(682773-53-1)

Safety Data

• Hazardous Substances Data: 682773-53-1(Hazardous Substances Data)

Upstream product

• 15103-48-7 pyridine-2-sulfonic acid 
• 34803-66-2 1-(2-pyridyl)piperazine 
• 98-80-6 phenylboronic acid 
• 5029-67-4 2-iodopyridine 
• 92-54-6 4-phenyl-1-piperazine 
• 372-48-5 2-fluoropyridine 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 108-95-2 phenol 
• 66950-63-8 phenyl N,N-dimethylsulfamate 
• 4920-92-7 pivalic acid phenyl ester 
• 109-09-1 2-chloropyridine 
• 100-70-9 2-Cyanopyridine 
• 109-04-6 2-bromo-pyridine 

Relevant articles and documents

Direct uncatalyzed amination of 2-chloropyridine using a flow reactor

Chloropyridines are efficiently converted into 2-amino-pyridines by uncatalyzed nucleophilic aromatic substitution (SNAr) in NMP using a continuous-flow reactor. A variety of secondary amines undergo SNAr with both electron-rich and electron-deficient 2-chloropyridines to afford 2-aminopyridines in good to excellent yield. The flow reactor, which provides a short reaction time and high temperatures up to 300°C, can overcome the activation barrier for reactions with unactivated substrates. Short reaction times result in fewer side products and can afford milligram to multigram quantities of product using continuous flow. Georg Thieme Verlag Stuttgart.

Ligand complex of copper (II) supported on superparamagnetic Fe3O4?SiO2 nanoparticles: an efficient and magnetically separable catalyst for N-arylation of nitrogen-containing heterocycles with aryl halides

In this study, we introduce the ligand complex of copper (II) supported on superparamagnetic Fe3O4?SiO2 nanoparticles as a highly intriguing magnetic catalyst in N-arylation of nitrogen heterocycles with aryl halides. The present methodology offers several advantages such as; low catalyst loading, the use of magnetically recoverable and reusable catalyst, high to excellent yields without using any external ligands or additives, short reaction times and simplicity of operation. Also, the magnetic catalyst could be easily separated from the final product by an external magnet and reused up to seven times without any significant loss of activity. Therefore, this separation strategy with negligible leaching makes Fe3O4?SiO2/ligand/Cu(II) an economical catalyst to perform this transformation.

Copper-catalyzed, ceric ammonium nitrate mediated N-arylation of amines

Cu-Catalyzed, ligand- and base-free cross-coupling of aryl boronic acids with primary and secondary amines has been reported. This ‘Chan-Evans-Lam' reaction has revealed that at room temperature, with a catalytic amount of copper(ii) acetate and ceric ammonium nitrate (CAN) as an oxidant, N-arylation can result in an effective C-N bond formation. This air stable, practical, robust protocol enables tolerance towards a variety of functional groups on both boronic acid and amine partners.