68279-50-5

Basic information

• Product Name: 2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide
• Synonyms: 2-(9H-Fluoren-9-ylidene)hydrazinecarbothioamide; Hydrazinecarbothioamide, 2-(9H-fluoren-9-ylidene)-
• CAS NO: 68279-50-5
• Molecular Formula: C₁₄H₁₁N₃S
• Molecular Weight: 253.3222
• Mol File: 68279-50-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 476.2°C at 760 mmHg
• Flash Point: 241.8°C
• Density: 1.35g/cm³
• Vapor Pressure: 3.11E-09mmHg at 25°C
• Refractive Index: 1.729
• CAS DataBase Reference: 2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide(68279-50-5)
• EPA Substance Registry System: 2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide(68279-50-5)

Safety Data

• Hazardous Substances Data: 68279-50-5(Hazardous Substances Data)

Usage

Physical state

yellow crystalline solid

Usage

organic synthesis, potential antifungal and antibacterial properties, pharmaceutical applications, corrosion inhibition, fluorescent probe in analytical chemistry

Importance

important building block in the preparation of other organic compounds

Upstream product

• 486-25-9 9-fluorenone 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 328117-44-8 2-(2-(9H-fluoren-9-ylidene)hydrazinyl)-4-(4-bromophenyl)thiazole 

Relevant articles and documents

Synthesis, characterization, and antitumor activity of some metal complexes with schiff bases derived from 9-fluorenone as a polycyclic aromatic compound

New bidendate Schiff base ligands HL1 [(9H-fluorene-9-ylidene)- thiosemicarbazide], HL2 [(9H-fluorene-9-ylidene)semicarbazide] and L3 [N1,N2-di(9H-fluorene-9-ylidene)ethan-1,2-diamine] derived from the condensation of thiosemicarbazide, semicarbazide, and ethylenediamine with 9-fluorenone as polycyclic aromatic compound (PAC). Ag(I), Cu(II), VO(IV), La(III), and Zn(II) of the ligands HL1, HL2, and L3 have been prepared and characterized by conductance and magnetic measurements, and electronic, infrared, and 1H NMR spectral data. Tetrahedral structures are suggested for Ag (I) with HL1, HL2, and L3, whereas Cu(II)-HL1 and VO(IV)-HL2 have octahedral and square-planar structures, respectively. The Erlich antitumor activity in vivo (E. A. A.) have been studied and showed that the free ligands L3, HL2, and its VO(IV)-HL2 complex are the most active in the inhibition of cell viability, whereas the ligands HL1, La(III) -L3, and Cu(II)-HL1 are the least active ones.

Ultrasound aided expedient synthesis, characterization and antimicrobial studies of fluorenyl-hydrazono-thiazole derivatives

Ultrasound assisted facile synthesis of fluorenyl-hydrazonothiazoles (4a-d) in quantitative yields by the condensation of 2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide (2) with substituted phenacyl bromides in presence of dimethyl formamide has been rep

Efficient "on water" green route heterocyclization of thiosemicarbazones with DMAD

A simple, efficient, and eco-friendly procedure for the synthesis of thiazolidin-4-one derivatives in water from cyclocondensation reaction of thiosemicarbazone derivatives and dimethylacetylene dicarboxylate (DMAD) in good yield is reported. The regiochemistry of the cyclized products is established by elemental analysis, IR, NMR, and mass spectral data. A single crystal X-ray diffraction study of a representative compound, 3f, is reported.