682805-45-4

Basic information

• Product Name: (2,5-dimethoxy-benzylidene)-malonic acid
• CAS NO: 682805-45-4
• Molecular Weight: 252.224
• Mol File: 682805-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,5-dimethoxy-benzylidene)-malonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-dimethoxy-benzylidene)-malonic acid(682805-45-4)
• EPA Substance Registry System: (2,5-dimethoxy-benzylidene)-malonic acid(682805-45-4)

Safety Data

• Hazardous Substances Data: 682805-45-4(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 105-53-3 diethyl malonate 
• 133031-79-5 dipotassium 2,5-dimethoxybenzylidenemalonate 
• 150-78-7 1,4-dimethoxybezene 
• 7324-87-0 diethyl 2-(2,5-dimethoxybenzylidene)malonate 

Downstream Products

• 20300-59-8 7-methoxycoumarin-3-carboxylic acid 

Relevant articles and documents

A One-Pot Synthesis of Coumarins from Dipotassium O-Methoxybenzylidenemalonates

o-Methoxybenzylidenemalonates 1, which are available from o-methoxybenzaldehydes and diethylmalonate, were hydrolysed to the dipotassium malonates 2.Treatment of the salts 2 with trifluoroacetic acid-trifluoroacetic anhydride gave the title coumarins by a demethylative ring-closure reaction in 60-80percent yield.