68281-66-3 Usage
General Description
6-Chloro-chroman-3-carboxylic acid methyl ester is a chemical compound belonging to the class of organic compounds known as benzo-fused seven-membered heterocyclic aromatic compounds. It bears a structural resemblance to chroman compounds and features a seven-membered ring structure fused to a benzene ring with a chlorine atom and a methyl ester group attached. The main potential usage of this chemical is in the research and development arena, particularly in synthetic chemistry. However, specific details about its properties such as toxicity, environmental impact or commercial applications are not widely documented, which is common for highly specialized or lesser-known compounds. It is crucial to handle this compound with proper protection and safety methods in a controlled environment.
Check Digit Verification of cas no
The CAS Registry Mumber 68281-66-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,8 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 68281-66:
(7*6)+(6*8)+(5*2)+(4*8)+(3*1)+(2*6)+(1*6)=153
153 % 10 = 3
So 68281-66-3 is a valid CAS Registry Number.
68281-66-3Relevant articles and documents
Lipase-mediated kinetic resolution of rigid clofibrate analogues with lipid-modifying activity
Ferorelli, Savina,Franchini, Carlo,Loiodice, Fulvio,Perrone, Maria Grazia,Scilimati, Antonio,Sinicropi, Maria Stefania,Tortorella, Paolo
, p. 853 - 862 (2007/10/03)
The lipase-catalysed kinetic resolution of methyl esters of (±)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acid, (±)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid, and (±)-6-chloro-2,3-dihydro-4H-1-benzopyran-3-carboxylic acid, rigid analogues of clofibrate, was effected with fair to moderate enantioselectivities (E = 1.0-4.8), enantiomeric excesses of up to 86% and workable reaction rates. Enantiomerically pure (R)- and (S)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acids were obtained by fractional crystallisation of the diastereomeric salts of the corresponding racemic acid with (+)- and (-)-amphetamine from ethanol; the absolute configuration of the products were established by chemical correlation.
