6829-40-9

Basic information

• Product Name: 2-AMINODIETHYLMALONATE
• Synonyms: AMINOMALONIC ACID DIETHYL ESTER;2-AMINODIETHYLMALONATE;DIETHYL AMINOMALONATE;Aminopropanedioicaciddiethylester;Ethylaminomalonate;DIETHYL AMINOMALINATE;2-Aminomalonic acid diethyl;2-Aminomalonic acid diethyl ester
• CAS NO: 6829-40-9
• Molecular Formula: C₇H₁₃NO₄
• Molecular Weight: 175.18
• EINECS: 229-905-0
• Product Categories: Pharmaceutical Intermediates;straight chain compounds;Amines;Intermediates
• Mol File: 6829-40-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 170 °C
• Boiling Point: 306.47°C (rough estimate)
• Flash Point: 52.3 °C
• Appearance: Colourless oil
• Density: 1.1000
• Refractive Index: 1.4353 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 15.34±0.59(Predicted)
• CAS DataBase Reference: 2-AMINODIETHYLMALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINODIETHYLMALONATE(6829-40-9)
• EPA Substance Registry System: 2-AMINODIETHYLMALONATE(6829-40-9)

Safety Data

• Hazardous Substances Data: 6829-40-9(Hazardous Substances Data)

Usage

Description

2-AMINODIETHYLMALONATE, a colorless oil, is an organic compound that serves as a crucial reagent in the synthesis of various chemical compounds, particularly imidazole derivatives. Its unique chemical structure allows it to be a versatile building block in the creation of a wide range of molecules with diverse applications across different industries.

Uses

Used in Pharmaceutical Industry:
2-AMINODIETHYLMALONATE is used as a reagent for the synthesis of imidazole derivatives, which are essential in the development of various pharmaceutical compounds. Imidazole derivatives have been found to possess a range of biological activities, including antifungal, antibacterial, antiviral, and anti-inflammatory properties. They are also used in the treatment of conditions such as hypertension, asthma, and allergies.
Used in Chemical Synthesis:
2-AMINODIETHYLMALONATE is used as a key intermediate in the synthesis of various organic compounds, particularly those containing the imidazole ring structure. This versatile reagent is employed in the production of a wide range of chemicals, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Research and Development:
2-AMINODIETHYLMALONATE is utilized as a valuable research tool in the development of new chemical entities and the study of their properties. Its role in the synthesis of imidazole derivatives makes it an essential component in the exploration of novel compounds with potential applications in various fields, such as medicine, agriculture, and materials science.

InChI:InChI=1/C7H14NO4/c1-3-7(8,4-2,5(9)10)6(11)12/h3-4,8H2,1-2H3,(H,9,10)(H,11,12)/p-2

Upstream product

• 6829-41-0 diethyl oximinomalonate 
• 603-67-8 diethyl nitromalonate 
• 105-53-3 diethyl malonate 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 6326-44-9 diethyl 2-formylaminomalonate 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 996-82-7 sodium diethylmalonate 
• 64-17-5 ethanol 
• 91469-69-1 ethylesters of amino malonic acid 
• 168207-98-5 diethyl 2,2-diazidomalonate 

Downstream Products

• 114282-94-9 (benzylsulfanylthiocarbonyl-amino)-malonic acid diethyl ester 
• 14769-29-0 diethyl 2-[[2-(benzyloxycarbonylamino)acetyl]amino]propanedioate 
• 500791-38-8 (2-phenyl-thioacetylamino)-malonic acid diethyl ester 
• 21024-83-9 Cbo-L-alanyl-aminomalonsaeurediethylester 
• 32683-00-4 ethyl 2-phenylimidazole-4-carboxylate 
• 62009-47-6 2-aminopropanediamide 
• 56-40-6 glycine 
• 617-45-8 aspartic Acid 
• 142-73-4 iminodiacetic acid 
• 609-36-9 rac-Pro-OH 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 96-86-6 diethyl benzamidomalonate 
• 54001-50-2 2-(3-phenylureido)malonic acid diethyl ester 
• 129221-15-4 2-(4-nitrobenzoylamino)propanedioic acid diethyl ester 

Relevant articles and documents

Regiochemistry in 1,3-dipolar cycloadditions of the azomethine ylide formed from diethyl aminomalonate and paraformaldehyde

The azomethine ylide derived from the condensation of diethyl aminomalonate with paraformaldehyde undergoes 1,3-dipolar cycloadditions with acrylate and propiolate derivatives. Contrary to a previous report, these reactions yield mixtures of regioisomers

AN IMPROVED HYDROGENATION PROCESS USING A TRANSITION METAL COMPLEX CATALYST

The present invention relates to the process of reduction of compound of formula (II) by using a transition metal complex (Z) as a catalyst for hydrogenation reactions to get compound of formula (I). More particularly, the present invention relates to an improved process for the preparation of a compound (I) (as described herein) or a salt thereof; comprising hydrogenation of the compound (II) (as described herein) using a transition metal complex catalyst (Z).

Preparation method of diethyl amino-malonate hydrochloride

The preparation method comprises first steps of preparing diethyl malonate in acetic acid, subnitration with an aqueous solution of nitrous acid to obtain the oxime-based malonic acid diethyl ester. 2nd: The oxime-based malonate is subjected to catalytic hydrogenation reaction with a nickel-containing ternary catalyst in an alcohol solvent to obtain diethyl amino-malonate. 3rd-Step: After the catalyst is filtered off, the catalyst is salified with hydrogen chloride ethanol and then dissolved in acetone to obtain diethyl amino-malonate hydrochloride. The method has the characteristics of mild and safe reaction conditions, simple and convenient operation, high yield, low cost, good quality and the like, and has wide application prospects. In addition, the hydrogenation technology for the method not only avoids waste residues and waste acid generated by reduction of zinc powder, but also avoids the disadvantages of expensive price and easy poisoning inactivation of the palladium-carbon catalyst.