68305-32-8

Basic information

• Product Name: 2(3H)-Benzoxazolone, 3-phenyl-
• CAS NO: 68305-32-8
• Molecular Formula: C13H9NO2
• Molecular Weight: 211.22
• Mol File: 68305-32-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2(3H)-Benzoxazolone, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzoxazolone, 3-phenyl-(68305-32-8)
• EPA Substance Registry System: 2(3H)-Benzoxazolone, 3-phenyl-(68305-32-8)

Safety Data

• Hazardous Substances Data: 68305-32-8(Hazardous Substances Data)

Upstream product

• 644-71-3 2-(phenylamino)phenol 
• 541-41-3 chloroformic acid ethyl ester 
• 591-50-4 iodobenzene 
• 56836-51-2 ethyl (2-hydroxyphenyl)carbamate 
• 95-55-6 2-amino-phenol 
• 95-56-7 2-hydroxybromobenzene 
• 17878-37-4 1-bromo-2-(trimethylsilyl)benzene 
• 59-49-4 2-Benzoxazolinone 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 75-44-5 phosgene 

Relevant articles and documents

Selective: S -arylation of 2-oxazolidinethiones and selective N -arylation of 2-benzoxazolinones/2-benzimidazolinones

There exist three possible patterns for the reaction of cyclic 2-oxazolidinethione and 2-benzoxazolidinethione with arynes, namely (a) S-arylation, (b) N-arylation, and (c) aryne insertion into the thiocarbonyl group (CS). Our studies demonstrate that S-arylation wins out affording S-aryl dihydrooxazoles. In contrast, for related reactions of cyclic 2-benzoxazolinone and 2-benzimidazolinone with arynes, it is found that N-arylation outcompetes O-arylation and aryne insertion into the CO group to give N-aryl 2-benzoxazolinones and N-aryl 2-benzimidazolinones.

Copper-Catalyzed One-Pot Synthesis of N -Aryl Oxazolidinones from Amino Alcohol Carbamates

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.