683224-24-0

Basic information

• Product Name: 4-phenylpiperazinecarbothioic acid hydrazide
• Synonyms: 4-phenylpiperazinecarbothioic acid hydrazide
• CAS NO: 683224-24-0
• Molecular Weight: 236.341
• Mol File: 683224-24-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-phenylpiperazinecarbothioic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylpiperazinecarbothioic acid hydrazide(683224-24-0)
• EPA Substance Registry System: 4-phenylpiperazinecarbothioic acid hydrazide(683224-24-0)

Safety Data

• Hazardous Substances Data: 683224-24-0(Hazardous Substances Data)

Upstream product

• 66962-18-3 4-N(phenyl)piperazino dithiocarbamate 
• 92-54-6 4-phenyl-1-piperazine 
• 21076-11-9 4-methyl-4-phenyl-3-thiosemicarbazide 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 

Downstream Products

• 926037-26-5 C₁₈H₂₁N₅S₂ 
• 1396785-81-1 (Z)-N’-(2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-84-4 (Z)-N’-(5-methyl-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396786-00-7 (Z)-N’-(5-methoxy-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-85-5 (Z)-N’-(5-bromo-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-87-7 (Z)-N’-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-88-8 (Z)-N’-(5-chloro-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-90-2 (Z)-N’-(5-fluoro-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-91-3 (Z)-N’-(5-nitro-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-92-4 (Z)-N’-(4-bromo-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-95-7 (Z)-N’-(4-chloro-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-96-8 (Z)-N’-(6-bromo-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 
• 1396785-98-0 (Z)-N’-(6-chloro-2-oxoindolin-3-ylidene)-4-phenylpiperazine-1-carbothiohydrazide 

Relevant articles and documents

Piperazinyl fragment improves anticancer activity of Triapine

A new class of TSCs containing piperazine (piperazinylogs) of Triapine, was designed to fulfill the di-substitution pattern at the TSCs N4 position, which is a crucial prerequisite for the high activity of the previously obtained TSC compounds–DpC and Dp4

Synthesis and antiproliferative evaluation of piperazine-1- carbothiohydrazide derivatives of indolin-2-one

By varying the substituents (R1) at the indolin-2-one scaffold, a series of indolin-2-one derivatives bearing 4-phenylpiperazine-1- carbothiohydrazide moiety at the C3-position were synthesized and evaluated for their antiproliferative activity against three human cancer cell lines. We further selected the 5-chloroindolin-2-one moiety for the extension to another series of compounds by varying the substituents (R2) at the phenyl group connected with the piperazine ring. Among all the compounds synthesized, 6d and 6l were most potent with IC50 values of 3.59 and 5.58 μM, respectively against A549 lung cancer cells, while 5f and 6l possessed IC 50 values of 3.49 and 4.57 μM, respectively against HCT-116 colon cancer cells which were comparable to that of Sunitinib, an indolin-2-one derivative in cancer therapy.

Synthesis and antibacterial activity of substituted thiosemicarbazides and of 1,3,4-thiadiazole or 1,2,4-triazole derivatives

The synthesized series of new thiosemicarbazide derivatives (1, 6-10) in reactions with carbon disulphide produced, according to the reaction conditions, the dithioacids (4, 30) or the 5-substituted l,3,4-thiadiazolo-2-thiol derivatives (2, 27). The dithi