683271-61-6

Basic information

• Product Name: 4-Piperidinamine, N-(phenylmethyl)-1-propyl-
• CAS NO: 683271-61-6
• Molecular Formula: C15H24N2
• Molecular Weight: 232.369
• Mol File: 683271-61-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Piperidinamine, N-(phenylmethyl)-1-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinamine, N-(phenylmethyl)-1-propyl-(683271-61-6)
• EPA Substance Registry System: 4-Piperidinamine, N-(phenylmethyl)-1-propyl-(683271-61-6)

Safety Data

• Hazardous Substances Data: 683271-61-6(Hazardous Substances Data)

Upstream product

• 23133-37-1 1-propyl-4-piperidone 
• 100-46-9 benzylamine 
• 41661-47-6 piperidin-4-one 
• 7285-11-2 chloroform methanol 

Downstream Products

• 683271-37-6 N,N-Diethyl-4-[benzyl(1-propylpiperidin-4-yl)amino]benzamide 

Relevant articles and documents

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

We previously discovered and validated a class of piperidinyl ureas that regulate defective in cullin neddylation 1 (DCN1)-dependent neddylation of cullins. Here, we report preliminary structure-activity relationship studies aimed at advancing our high-throughput screen hit into a tractable tool compound for dissecting the effects of acute DCN1-UBE2M inhibition on the NEDD8/cullin pathway. Structure-enabled optimization led to a 100-fold increase in biochemical potency and modestly increased solubility and permeability as compared to our initial hit. The optimized compounds inhibit the DCN1-UBE2M protein-protein interaction in our TR-FRET binding assay and inhibit cullin neddylation in our pulse-chase NEDD8 transfer assay. The optimized compounds bind to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line. Ultimately, we anticipate that these studies will identify early lead compounds for clinical development for the treatment of lung squamous cell carcinomas and other cancers.