6833-15-4

Basic information

• Product Name: 4-CHLOROBENZANILIDE
• Synonyms: 4-CHLOROBENZANILIDE;4-Chloro-N-phenylbenzamide;N-Phenyl-4-chlorobenzamide;N-Phenyl-p-chlorobenzamide;4-Chlorobenzanilide,98%
• CAS NO: 6833-15-4
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 231.68
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 6833-15-4.mol
• Article Data: 146

Chemical Properties

• Melting Point: 199-201 °C(lit.)
• Boiling Point: 288.6 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /Solid
• Density: 1.285 g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLOROBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROBENZANILIDE(6833-15-4)
• EPA Substance Registry System: 4-CHLOROBENZANILIDE(6833-15-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 6833-15-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10ClNO/c14-11-8-6-10(7-9-11)13(16)15-12-4-2-1-3-5-12/h1-9H,(H,15,16)

Upstream product

• 2998-98-3 (Z)-(4-chlorophenyl)(phenyl)methanone oxime 
• 104-88-1 4-chlorobenzaldehyde 
• 103-71-9 phenyl isocyanate 
• 108-90-7 chlorobenzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 62-53-3 aniline 
• 1871-38-1 phenyl 4-chlorobenzoate 
• 28122-82-9 S-phenyl 4-chlorobenzothioate 
• 74-11-3 para-chlorobenzoic acid 
• 59318-25-1 p-Chlorobenzoylthiochlorosulfit 
• 13014-48-7 4-chlorobenzoyl cyanide 
• 109310-00-1 N,O-bis-(4-chloro-benzoyl)-N-phenyl-hydroxylamine 
• 67-56-1 methanol 
• 14064-15-4 (4-chlorophenyl)trimethylstannane 

Downstream Products

• 65786-54-1 4'-chloro-4-dimethylamino-2-methyl-benzophenone 
• 105702-86-1 4-chloro-4'-(N-methyl-anilino)-benzophenone 
• 37613-10-8 4-chloro-N-phenyl-benzimidoyl chloride 
• 129120-25-8 (4-chlorophenyl)(4-(dimethylamino)phenyl)methanone 
• 91790-87-3 N,N'-diphenyl-4-chlorobenzamidine 
• 104689-75-0 (4-chlorophenyl)(4-(diethylamino)phenyl)methanone 
• 54595-71-0 6-chloro-1'-methyl-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 54595-72-1 1'-benzyl-6-chloro-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 5892-88-6 (4-Chloro-benzoyl)-phenyl-carbamic acid 2-chloro-1-methyl-ethyl ester 
• 5892-83-1 (4-Chloro-benzoyl)-phenyl-carbamic acid 2-methoxy-1-methyl-ethyl ester 
• 5892-74-0 (4-Chloro-benzoyl)-phenyl-carbamic acid isopropyl ester 
• 122399-73-9 3-<4-(4-chlorobenzoylamino)benzoyl>acrylic acid 
• 63471-86-3 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid 
• 146516-72-5 4-chloro-2-trimethylsilyl-benzanilide 

Relevant articles and documents

TBAI-catalyzed C–N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides

A new green approach for the synthesis of amide through TBAI-catalyzed oxidative coupling of benzyl bromides with amine was developed in the presence of tert-butyl hydroperoxide (TBHP) as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines, were subjected to the reaction and transformed to the corresponding amide in good to excellent yields.

Fe-mediated synthesis of: N -aryl amides from nitroarenes and acyl chlorides

Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant and additive, and the reaction can be easily performed on a large scale.

Manganese Catalyzed Direct Amidation of Esters with Amines

The transition metal catalyzed amide bond forming reaction of esters with amines has been developed as an advanced approach for overcoming the shortcomings of traditional methods. The broad scope of substrates in transition metal catalyzed amidations remains a challenge. Here, a manganese(I)-catalyzed method for the direct synthesis of amides from a various number of esters and amines is reported with unprecedented substrate scope using a low catalyst loading. A wide range of aromatic, aliphatic, and heterocyclic esters, even in fatty acid esters, reacted with a diverse range of primary aryl amines, primary alkyl amines, and secondary alkyl amines to form amides. It is noteworthy that this approach provides the first example of the transition metal catalyzed amide bond forming reaction from fatty acid esters and amines. The acid-base mechanism for the manganese(I)-catalyzed direct amidation of esters with amines was elucidated by DFT calculations.