6833-19-8

Basic information

• Product Name: N-phenyl-1-naphthamide
• Synonyms: N-phenyl-1-naphthamide;N-Phenyl-1-naphthalenecarboxamide;N-Phenylnaphthalene-1-carboxamide
• CAS NO: 6833-19-8
• Molecular Formula: C₁₇H₁₃NO
• Molecular Weight: 247.29122
• Mol File: 6833-19-8.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 347.6°Cat760mmHg
• Flash Point: 210.2°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 5.31E-05mmHg at 25°C
• Refractive Index: 1.705
• CAS DataBase Reference: N-phenyl-1-naphthamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-1-naphthamide(6833-19-8)
• EPA Substance Registry System: N-phenyl-1-naphthamide(6833-19-8)

Safety Data

• Hazardous Substances Data: 6833-19-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H13NO/c19-17(18-14-9-2-1-3-10-14)16-12-6-8-13-7-4-5-11-15(13)16/h1-12H,(H,18,19)

Upstream product

• 642-29-5 1-benzoylnaphthalene 
• 14271-86-4 1-naphthoyl cyanide 
• 62-53-3 aniline 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 4921-84-0 N-(naphthalen-1-ylcarbamothioyl)benzamide 
• 944-85-4 1-(trimethylstannyl)naphthalene 
• 103-71-9 phenyl isocyanate 
• 87503-49-9 N-(1-naphthoyl)-O-(p-toluoyl)-N-phenylhydroxylamine 
• 87503-51-3 N,O-di(1-naphthoyl)-N-phenylhydroxylamine 
• 85924-97-6 1H-cyclobutanaphthalen-1-one 
• 93-98-1 N-phenyl benzoyl amide 
• 183175-18-0 N-(1-naphthoyl)-N-phenyl-O-(4-benzoylbenzoyl)hydroxylamine 
• 201230-82-2 carbon monoxide 
• 90-11-9 1-Bromonaphthalene 

Downstream Products

• 6321-57-9 5-(naphthalen-1-yl)-1-phenyl-1H-tetrazole 
• 101601-73-4 [1]naphthyl-(1-phenyl-1H-tetrazol-5-yl)-amine 
• 872798-01-1 N-phenyl-1-naphthylacetimidoyl chloride 
• 66-77-3 1-naphthaldehyde 
• 83738-56-1 (4-dimethylamino-phenyl)-[1]naphthyl ketone 
• 5892-82-0 (Naphthalene-1-carbonyl)-phenyl-carbamic acid isopropyl ester 
• 259817-02-2 methyl 2-diazo-3-[N-(1-naphthoyl)-N-phenylamino]-3-oxopropanoate 
• 259817-08-8 5-methoxycarbonyl-2-(1-naphthyl)-3-phenyl-1,3-oxazolium-4-olate 
• 119656-55-2 N-(1-Naphthoyl)-N-phenylglycine 
• 66920-75-0 4-(naphthalen-1-yl)but-3-en-2-one 
• 3506-84-1 4-(1-naphthyl)-2-butanone 
• 1253388-59-8 C₂₅H₂₅NO 
• 1253388-58-7 C₃₁H₂₁NO 
• 1256360-92-5 C₂₇H₂₁NO₃ 

Relevant articles and documents

Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts

By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).

Chromium-catalyzed ligand-free amidation of esters with anilines

Amides are important structural motifs in pharmaceutical and agrochemical chemistry because of the intriguing biological active properties. We report here the amidation of commercially available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution.

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.