6834-98-6 Usage
Description
Fungichromin is a pentaene antifungal compound produced by Streptomyces, first isolated in 1958. It is structurally identified as 14-hydroxyfilipin III and is the most polar member of the filipin family of fungicides. Fungichromin possesses broad-spectrum antifungal and antitumor activity, acting through interaction with cell membrane sterols.
Uses
Used in Pharmaceutical Industry:
Fungichromin is used as an antifungal agent for its broad-spectrum antifungal activity, targeting a wide range of fungal infections by interacting with cell membrane sterols.
Used in Oncology:
Fungichromin is used as an antitumor agent for its demonstrated antitumor activity, potentially offering therapeutic benefits in cancer treatment by interacting with cell membrane sterols and affecting cancer cell growth.
Biological Activity
lagosin, a polyene macrolide antibiotic, has first been extracted from an isolate of a streptomyces species present in a sample of soil collected in lagos, nigeria [1]. it has been reported that the three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, showed some stereochemical differences at one or more centers [1].lagosin was the most polar member of the filipin family of fungicides with broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols. the antibiotic lagosin, which appeared to be identical to, or a stereoisomer of, fungichromin, and was very similar in structure to the filipins [2]. the equilibrium constants for association of the polyene antibiotics with aqueous suspensions of cholesterol follow the order filipin iil > amphotericin b > nystatin > lagosin, in agreement with the order reported for the extent of damage these antibiotics cause in natural and model membranes [2].
references
[1] pandey r c, guenther e c, aszalos a a, et al. physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin[j]. the journal of antibiotics, 1982, 35(8): 988-996.[2] bittman r, fischkoff s a. fluorescence studies of the binding of the polyene antibiotics filipin iii, amphotericin b, nystatin, and lagosin to cholesterol[j]. proceedings of the national academy of sciences, 1972, 69(12): 3795-3799.
Check Digit Verification of cas no
The CAS Registry Mumber 6834-98-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,3 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6834-98:
(6*6)+(5*8)+(4*3)+(3*4)+(2*9)+(1*8)=126
126 % 10 = 6
So 6834-98-6 is a valid CAS Registry Number.
InChI:InChI=1/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+/t23-,24+,25-,26+,27-,28+,29-,30+,31-,32-,33-,34-/m1/s1
