68348-23-2Relevant articles and documents
Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases
Lespérance, Maxime,Roy, Jenny,Djiemeny Ngueta, Adrien,Maltais, René,Poirier, Donald
, (2021/05/17)
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2). These enzymes are known to play a pivotal role in the progression of estrogen-depen
(Z)-3-(3-formyl benzylidene) piperazinedione type compound and application thereof to preparation of anti-tumor medicine
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Paragraph 0115; 0118-0120, (2019/10/01)
The invention discloses a (Z)-3-(3-formyl benzylidene) piperazinedione type compound and application thereof to preparation of anti-tumor medicine. In a general formula (I) shown as the accompanying drawing, Rl is selected from substituted or nonsubstituted saturated nitrogen-containing multivariate heterocycles, substituted or nonsubstituted unsaturated sulfur-containing multivariate heterocycles, and substituted or nonsubstituted unsaturated oxygen containing multivariate heterocycles, and the multivariate heterocycles are 4 to 6 membered heterocycles. R2 is 5-tertiary butyl-1H-imidazole or pyridine. The invention also discloses a purpose of the compound to preparation of medicine composition aspects for treating tumor diseases, particularly, purposes to preparation of medicine compositions for treating pancreatic cancer and/or lung cancer aspects.
Synthesis of optically active thromboxane A2 and Leukotriene D4 receptor antagonists
Kawazoe, Souichirou,Okamoto, Yoshinori,Yokota, Masaki,Kubota, Hirokazu,Naito, Ryo,Takeuchi, Makoto,Ieda, Shigeru,Okada, Minoru,Oriyama, Takeshi
, p. 127 - 140 (2014/02/14)
Both (+)- and (-)-4-{[(2-{4-cUorophenylsulfonylamino}-1-{3-[(Q-2-(7-cWoro- 2-quinolyl)-vinyl]phenyl}ethyl)-thio]methyl}benzoic acid (1), Thromboxane A2 and Leukotriene D4 receptor dual antagonist were synthesized. Racemic methyl 4-({[2-amino-1-(3-hydroxym