683800-09-1

Basic information

• Product Name: Propanedioic acid, 2-cyclohexen-1-yl[(1-methyl-1H-indol-2-yl)methyl]-, dimethyl ester
• CAS NO: 683800-09-1
• Molecular Formula: C21H25NO4
• Molecular Weight: 355.434
• Mol File: 683800-09-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, 2-cyclohexen-1-yl[(1-methyl-1H-indol-2-yl)methyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, 2-cyclohexen-1-yl[(1-methyl-1H-indol-2-yl)methyl]-, dimethyl ester(683800-09-1)
• EPA Substance Registry System: Propanedioic acid, 2-cyclohexen-1-yl[(1-methyl-1H-indol-2-yl)methyl]-, dimethyl ester(683800-09-1)

Safety Data

• Hazardous Substances Data: 683800-09-1(Hazardous Substances Data)

Upstream product

• 18424-76-5 dimethyl malonate sodium salt 
• 1485-22-9 (1-methyl-1H-indol-2-yl)-methanol 
• 2441-97-6 3-chloro-cyclohexene 
• 656228-35-2 dimethyl 2-(2-(N-methyl)indolylmethyl)propanedioate 

Relevant articles and documents

Platinum-Catalyzed Intramolecular Alkylation of Indoles with Unactivated Olefins

Reaction of 1-methy-2-(4-pentenyl)indole (1) with a catalytic amount of PtCl2 (2 mol %) in dioxane that contained a trace of HCl (5 mol %) at 60 °C for 24 h led to the isolation of 4,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazole (2) in 92% yield. Platinum-catalyzed cyclization of 2-(4-pentenyl)indoles tolerated substitution at each position of the 4-pentenyl chain. Furthermore, the protocol was applicable to the synthesis of tetrahydro-β-carbolinones and was effective for cyclization of unprotected indoles. 2-(3-Butenyl)indoles underwent platinum-catalyzed cyclization with exclusive 6-endo-trig regioselectivity. Mechanistic studies established a mechanism for the platinum-catalyzed cyclization of 2-alkenyl indoles involving nucleophilic attack of the indole on a platinum-complexed olefin. Copyright