68399-78-0

Basic information

• Product Name: N-(Hydroxyethyl)piperazine-N'-2-hydroxypropanesulfonic acid
• Synonyms: 4-(2-hydroxyethyl)piperazine-1-(2-hydr.prop.sulf.ac.)1h2o;beta-hydroxy-4-(2-hydroxyethyl)-1-piperazinepropanesulfonicaci;N-(2-HYDROXYETHYL)PIPERAZINE-N'-2-HYDROXY PROPANESULPHONIC ACID;N-[2-HYDROXYETHYL]PIPERAZINE-N'-[2-HYDROXYPROPANESULFONIC ACID;4-(2-HYDROXYETHYL)PIPERAZINE-1-(2-HYDROXYPROPANE-3-SULFONIC ACID);4-(2-HYDROXYETHYL)PIPERAZINE-1-(2-HYDROXYPROPANESULFONIC ACID);3-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-HYDROXYPROPANESULFONIC ACID;HEPPSO
• CAS NO: 68399-78-0
• Molecular Formula: C₉H₂₀N₂O₅S
• Molecular Weight: 268.33
• EINECS: 269-990-1
• Product Categories: Pharmaceutical Intermediates;Biochemistry;Good's Buffers;Buffer
• Mol File: 68399-78-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 158-160°C
• Appearance: /
• Density: 1.382 g/cm³
• Refractive Index: 1.56
• PKA: 1.10±0.50(Predicted)
• Water Solubility: almost transparency in Water
• CAS DataBase Reference: N-(Hydroxyethyl)piperazine-N'-2-hydroxypropanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Hydroxyethyl)piperazine-N'-2-hydroxypropanesulfonic acid(68399-78-0)
• EPA Substance Registry System: N-(Hydroxyethyl)piperazine-N'-2-hydroxypropanesulfonic acid(68399-78-0)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36-45-24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 68399-78-0(Hazardous Substances Data)

Usage

Description

N-(Hydroxyethyl)piperazine-N'-2-hydroxypropanesulfonic acid, commonly known as HEPPSO, is a zwitterionic buffer with the chemical formula C7H16N2O5S. It is a white solid and is widely used in the pharmaceutical industry for the manufacturing of advanced therapy medication products.

Uses

Used in Pharmaceutical Industry:
HEPPSO is used as a buffer in the Good Manufacturing Practice (GMP) manufacturing of advanced therapy medication products. Its zwitterionic nature allows it to maintain a stable pH in various conditions, making it an essential component in the formulation and production of pharmaceuticals.
Used in Research Applications:
HEPPSO is also utilized as a buffer in various research applications, such as cell culture, enzyme assays, and other biochemical experiments. Its ability to maintain a stable pH and its compatibility with a wide range of biological systems make it a preferred choice for researchers.
Used in Diagnostic Applications:
In the field of diagnostics, HEPPSO is employed as a buffer in the development and production of diagnostic kits and reagents. Its stability and compatibility with various diagnostic targets contribute to the accuracy and reliability of diagnostic tests.

InChI:InChI=1/C9H20N2O5S/c12-6-5-10-1-3-11(4-2-10)7-9(13)8-17(14,15)16/h9,12-13H,1-8H2,(H,14,15,16)

Relevant articles and documents

Amino-hydroxy-alkyl sulfonic acid zwitterions

Novel amino-hydroxy-alkylene sulfonic acid zwitterions are described which have the general formulas STR1 wherein A and B are each independently a hydrogen atom, an aliphatic, cycloaliphatic or hydroxyaliphatic group, N is one or two, and R=n is a cyclic radical comprising one or two ring nitrogen atoms, zero or one ring oxygen atoms and the remainder of the ring being carbon atoms, and water soluble salts of said acids. These organo-sulfonic acid compounds are useful as hydrogen ion buffers in biological research and particularly for tissue culture.