684250-21-3

Basic information

• Product Name: 2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline
• Synonyms: 2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline
• CAS NO: 684250-21-3
• Molecular Formula: C₁₁H₁₃F₂NSi
• Molecular Weight: 225.3099264
• Mol File: 684250-21-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline(684250-21-3)
• EPA Substance Registry System: 2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline(684250-21-3)

Safety Data

• Hazardous Substances Data: 684250-21-3(Hazardous Substances Data)

Usage

General Description

2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline is a chemical compound that consists of a benzene ring with two fluorine atoms at the 2 and 4 positions, and a trimethylsilyl group attached to the ethynyl group at the 6 position. It is used in organic synthesis as a reagent for the construction of complex molecules and as a building block for pharmaceuticals, agrochemicals, and materials. It is also used as a precursor for the synthesis of novel organic electronic materials and in the preparation of functional polymers. Because of its unique structure and reactivity, 2,4-Difluoro-6-((triMethylsilyl)ethynyl)aniline has applications in a variety of fields including chemistry, medicine, and materials science.

Upstream product

• 444-14-4 2-bromo-4,6-difluoroaniline 
• 1066-54-2 trimethylsilylacetylene 
• 367-25-9 2,4-difluorophenylamine 
• 582319-15-1 2,4-difluoro-6-iodo-aniline 

Relevant articles and documents

Polycyclic compound and preparation method and application thereof

The invention discloses a polycyclic compound and a preparation method and application thereof. The invention provides a polycyclic compound shown as a formula I or a pharmaceutically acceptable saltthereof. The compound has a relatively good inhibition effect on CDK7.

CuI-Catalyzed intramolecular aminocyanation of terminal alkynes in N-(2-ethynylphenyl)-N-sulfonylcyanamides via Cu-vinylidene intermediates

CuI-Catalyzed intramolecular aminocyanation of terminal alkynes in N-(2-ethynylphenyl)-N-sulfonylcyanamides was initiated by the formation of Cu-acetylide to trigger N-CN bond cleavage of the N-sulfonylcyanamide moiety followed by CN migration to form a β-cyano Cu-vinylidene intermediate. Subsequently, the indole ring closure furnished the corresponding 1-sulfonyl-3-cyanoindoles.

Gold(III)-catalyzed annulation of 2-alkynylanilines: A mild and efficient synthesis of indoles and 3-haloindoles

Gold(III)-catalyzed annulation of 2-alkynylanilines in EtOH or EtOH-water mixtures at room temperature gives indoles derivatives in good yields. One-flask protocol for the gold-catalyzed conversion of 2-alkynylanilines to 3-bromo and 3-iodoindoles is also reported.