68426-53-9 Usage
Source
Derived from the camptothecin family of natural alkaloid compounds.
Potency
Known for its potent anti-cancer properties.
Mechanism of action
Acts as a topoisomerase 1 inhibitor.
DNA replication interference
Interferes with the ability of cancer cells to replicate their DNA.
Cell death
Leads to cell death in cancer cells.
Preclinical studies
Shown promising results in preclinical studies.
Cancer types
Potential therapeutic agent for various types of cancer, including lung, breast, and ovarian cancer.
Additional activities
Exhibits anti-inflammatory and anti-viral activities.
Versatility
A versatile compound with potential applications in medical and pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 68426-53-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,4,2 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 68426-53:
(7*6)+(6*8)+(5*4)+(4*2)+(3*6)+(2*5)+(1*3)=149
149 % 10 = 9
So 68426-53-9 is a valid CAS Registry Number.
68426-53-9Relevant articles and documents
Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins
Sawada,Matsuoka,Nokata,Nagata,Furuta,Yokokura,Miyasaka
, p. 3183 - 3188 (2007/10/02)
20(S)-Camptothecin derivatives having nitro, amino, chloro, bromo, hydroxyl and methoxyl groups in the A-ring were synthesized. B-Ring hydrogenated camptothecin (2a) was converted into 10-hydroxycamptothecin (6e) by treatment with lead tetraacetate in trifluoroacetic acid. 10-Substituted derivatives (6) were obtained by a photoreaction of N-oxides (9). The cytotoxicity of the A-ring modified camptothecins was evaluated against KB cells in vitro and leukemia L1210 in mice. 7-Ethyl-10-hydroxycamptothecin (6i) was identified as a potential derivative for further modification.
