68432-16-6Relevant articles and documents
Hydrogen-Atom Transfer Oxidation with H2O2 Catalyzed by [FeII(1,2-bis(2,2′-bipyridyl-6-yl)ethane(H2O)2]2+: Likely Involvement of a (μ-Hydroxo)(μ-1,2-peroxo)diiron(III) Intermediate
Khenkin, Alexander M.,Vedichi, Madhu,Shimon, Linda J. W.,Cranswick, Matthew A.,Klein, Johannes E. M. N.,Que, Lawrence,Neumann, Ronny
, p. 990 - 998 (2017/09/25)
The iron(II) triflate complex (1) of 1,2-bis(2,2′-bipyridyl-6-yl)ethane, with two bipyridine moieties connected by an ethane bridge, was prepared. Addition of aqueous 30 % H2O2 to an acetonitrile solution of 1 yielded 2, a green compound with λmax=710 nm. Moessbauer measurements on 2 showed a doublet with an isomer shift (δ) of 0.35 mm/s and a quadrupole splitting (ΔEQ) of 0.86 mm/s, indicative of an antiferromagnetically coupled diferric complex. Resonance Raman spectra showed peaks at 883, 556 and 451 cm?1 that downshifted to 832, 540 and 441 cm?1 when 1 was treated with H2 18O2. All the spectroscopic data support the initial formation of a (μ-hydroxo)(μ-1,2-peroxo)diiron(III) complex that oxidizes carbon-hydrogen bonds. At 0 °C 2 reacted with cyclohexene to yield allylic oxidation products but not epoxide. Weak benzylic C?H bonds of alkylarenes were also oxidized. A plot of the logarithms of the second order rate constants versus the bond dissociation energies of the cleaved C?H bond showed an excellent linear correlation. Along with the observation that oxidation of the probe substrate 2,2-dimethyl-1-phenylpropan-1-ol yielded the corresponding ketone but no benzaldehyde, and the kinetic isotope effect, kH/kD, of 2.8 found for the oxidation of xanthene, the results support the hypothesis for a metal-based H-atom abstraction mechanism. Complex 2 is a rare example of a (μ-hydroxo)(μ-1,2-peroxo)diiron(III) complex that can elicit the oxidation of carbon-hydrogen bonds.
Fused polycyclic 2-aminopyrimidine derivatives
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, (2008/06/13)
Fused polycyclic 2-aminopyrimidines of formula (1) are described: wherein R1 is a group -L1 R2 where L1 is a covalent bond or a linker atom or group and R2 is a group -(Alk)mL2R3 where Alk is an optionally substituted aliphatic or heteroaliphatic chain, m is zero or the integer 1, L2 is a covalent bond or a linker atom or group and R3 is an optionally substituted cycloaliphatic or heterocycloaliphatic group provided that when m is zero L2 is a covalent bond; Ar is an aryl or heteroaryl group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are potent and selective inhibitors of protein kinases, especially src-family protein kinases and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to have a role.
Decalin ketones, their use in perfumery and process for the preparation thereof
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, (2008/06/13)
The decalin ketones of formula STR1 having a single or double bond in one of the positions indicated by the dotted lines, or two double bonds in positions 2 and 5 or 3 and 5 such as indicated by the dotted lines, and wherein symbols R1, R2