68453-56-5

Basic information

• Product Name: Methyl 4-(MorpholinoMethyl)benzoate
• Synonyms: Methyl 4-(MorpholinoMethyl)benzoate
• CAS NO: 68453-56-5
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.27898
• Mol File: 68453-56-5.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 4-(MorpholinoMethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(MorpholinoMethyl)benzoate(68453-56-5)
• EPA Substance Registry System: Methyl 4-(MorpholinoMethyl)benzoate(68453-56-5)

Safety Data

• Hazardous Substances Data: 68453-56-5(Hazardous Substances Data)

Usage

General Description

Methyl 4-(MorpholinoMethyl)benzoate, also known as MMMP, is a chemical compound frequently used in organic synthesis and pharmaceutical research. It is an ester derivative of benzoic acid and contains a morpholine ring, making it a versatile building block for drug discovery. MMMP has been studied for its potential use in the development of various medications, including antimicrobial and antiviral drugs. Its unique chemical structure and reactivity make it a valuable tool for drug development and chemical research. Additionally, MMMP has shown promise in the field of medicinal chemistry for the synthesis of biologically active compounds, making it an important and valuable chemical in pharmaceutical research.

Upstream product

• 110-91-8 morpholine 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Downstream Products

• 91271-65-7 (4-morpholin-4-ylmethyl-phenyl)-methanol 
• 65101-82-8 4-(4-morpholinylmethyl)benzoic acid hydrochloride 
• 934221-39-3 N-(N-(4-morpholinomethylbenzoyl)-L-phenylalanyl)-L-phenylalanol 
• 1338250-31-9 N-(N-(4-morpholinomethylbenzoyl)-L-phenylalanyl)-O-acetyl-L-phenylalanol 
• 1354657-80-9 2-[4-(tert-butyldimethylsilanyloxy)benzenesulfonyl]-1-(4-morpholin-4-ylmethylphenyl)ethanone 
• 82413-63-6 4-(morpholin-4-ylmethyl)benzaldehyde 
• 62642-62-0 4-(morpholinomethyl)benzoic acid 
• 123742-32-5 4-(4-Morpholinylmethyl)benzoyl chloride 

Relevant articles and documents

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

IMMUNOMODULATORY COMPOUNDS

Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

METHODS FOR TREATING PATIENTS WITH CANCER HAVING DEFECTS IN CYCLIN D REGULATION

The present disclosure relates to methods of treating cancer comprising administering Parkin ligase activator or a pharmaceutically acceptable salt thereof to a subject who has a mutant form of a protein in the Rb checkpoint pathway. The Parkin ligase activator includes triazole compounds, such as compounds of formula (I), and pharmaceutically acceptable salts thereof as disclosed herein. R1, R2, R3, M1, M2, M3, L1, L2, and L3 are as defined herein.