68491-55-4Relevant articles and documents
Synthesis and antimicrobial activity of nitrobenzyl-oxy-phenol derivatives
Mohamed, Malik Suliman,Maki, Toshihide,Shah, Mohammad Monir,Ichinose, Yoshio
, p. 1888 - 1892 (2016)
Two hydroquinone derivatives were prepared and their antimicrobial activity evaluated. Their minimum inhibitory concentrations (MICs) were determined using a broth dilution method. Gentamycin and ciprofloxacin were used as reference antibiotics. The antimicrobial activity of 4-(benzyloxy)phenol (monobenzone) was also evaluated based on its structural similarity to the new compounds; activity was comparable to that of 3,5-dimethyl-4-((4-nitrobenzyl)oxy)phenol (4a). 2,3,5-Trimethyl-4-((4-nitrobenzyl)oxy)phenol (4b) exhibited the best antibacterial activity against both clinical isolates and type strain of Moraxella catarrhalis (M. catarrhalis), with a MIC value of 11 μM, comparable to ciprofloxacin 9 μM.
Choice of Manganese(III) Complexes for the Synthesis of 4,4'-Biphenyldiols and 4,4'-Diphenoquinones
Nishino, Hiroshi,Nobuyuki, Itoh,Nagashima, Makiko,Kurosawa, Kazu
, p. 620 - 622 (2007/10/02)
2,6-Disubstituted phenols are oxidized with tris(2,4-pentanedionato)manganese(III), , in glacial acetic acid to give the corresponding 4,4'-biphenyldiols in high yields, whereas similar reactions using manganase(III) acetate, , instead of quantitatively yield the corresponding 4,4'-diphenoquinones.Cross-coupling reactions of 2,6-di-t-butylphenol and other substituted phenols afford the corresponding cross-coupled 4,4'-biphenyldiols and 4,4'-diphenoquinones together with oxidation products derived from them starting phenols themselves.The advantageous use of and Mn(OAc)3> in the ubiqitous phenol coupling reaction is discussed.
