6851-81-6 Usage
Description
1,5,5-Trimethylhydantoin (TMH) is a 1,5,5-trisubstituted hydantoin, which is a white to off-white crystalline powder. Its mass spectrum has been recorded and analyzed, and it has a density of 1.1318g/ml at 25°C.
Uses
Used in Chemical Synthesis:
1,5,5-Trimethylhydantoin is used as a chemical intermediate for the synthesis of various compounds, including 3-bromomethyl-1,5,5-trimethylimidazolidine-2,4-dione. This application is due to its unique chemical structure, which allows for further functionalization and the creation of a range of different products.
Used in Pharmaceutical Industry:
1,5,5-Trimethylhydantoin is used as a building block for the development of new pharmaceutical compounds. Its application in this industry is due to its potential to be incorporated into the molecular structure of drugs, potentially enhancing their efficacy or modifying their properties.
Used in Research and Development:
1,5,5-Trimethylhydantoin is used as a research compound for studying its chemical properties and potential applications in various fields. The reason for its use in research and development is to gain a deeper understanding of its reactivity, stability, and possible interactions with other molecules, which could lead to new discoveries and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 6851-81-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,5 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6851-81:
(6*6)+(5*8)+(4*5)+(3*1)+(2*8)+(1*1)=116
116 % 10 = 6
So 6851-81-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2O2/c1-6(2)4(9)7-5(10)8(6)3/h1-3H3,(H,7,9,10)
6851-81-6Relevant articles and documents
Ring-Transformation of Imidazolidine-2,4-diones ( = Hydantoins ) to 4H-Imidazoles in the Reaction with 3-(Dimethylamino)-2,2-dimethyl-2H-azirines
Schlaepfer-Daehler, Marlise,Mukherjee-Mueller, Gabriele,Heimgartner, Heinz
, p. 1251 - 1261 (2007/10/02)
At ca. 70 deg C, 3-(dimethylamino)-2,2-dimethyl-2H-azirine (1) and 5,5-disubstituted hydantoins 4 in MeCN or i-PrOH give 2-(1-aminoalkyl)-5-(dimethylamino)-4,4-dimethyl-4H-imidazoles 5 in good yield (Scheme 2).These products are decarboxylated 1:1 adducts of 1 and 4.A reaction mechanism is suggested in analogy to the previously reported reactions of 1 and NH-acidic heterocycles containing the CO-NH-CO-NH moiety (Scheme 5).The formation of ureas 6 and 7 can be rationalized by trapping the intermediate isocyanate F by an amine.No reaction is observed between 1 and 1,5,5- or 3,5,5-trisubstituted hydantoins in refluxing MeCN or i-PrOH, but an N-isopropylation of 1,5,5-trimethylhydantoin (8b) occurs in the presence of morpholine (Scheme 3).The reaction of the bis(azirine)dibromozink complex 11 and hydantoines 4 in refluxing MeCN yields zink complexes 12 of the corresponding 2-(1-aminoalkyl)-4H-imidazoles 5 (Scheme 4).
