685903-46-2

Basic information

• Product Name: S-(p-tolyl) 5-formylfuran-2-carbothioate
• Synonyms: S-(p-tolyl) 5-formylfuran-2-carbothioate
• CAS NO: 685903-46-2
• Molecular Weight: 246.287
• Mol File: 685903-46-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: S-(p-tolyl) 5-formylfuran-2-carbothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(p-tolyl) 5-formylfuran-2-carbothioate(685903-46-2)
• EPA Substance Registry System: S-(p-tolyl) 5-formylfuran-2-carbothioate(685903-46-2)

Safety Data

• Hazardous Substances Data: 685903-46-2(Hazardous Substances Data)

Upstream product

• 106871-53-8 2-(p-tolylthio)-2-oxoacetic acid 
• 106-45-6 para-thiocresol 
• 2689-65-8 5-iodofuran-2-carbaldehyde 

Relevant articles and documents

Oxalic Acid Monothioester for Palladium-Catalyzed Decarboxylative Thiocarbonylation and Hydrothiocarbonylation

Oxalic acid monothioester (OAM), an easily accessible and storable reagent, was reported herein as a thioester synthetic equivalent for palladium-catalyzed decarboxylative thiocarbonylation of organohalides and hydrothiocarbonylation of unsaturated carbon-carbon bonds at room temperature with high chemo- and regioselectivity. The reaction is applicable to the synthesis of cysteine-derived thioesters, thus allowing chemical modification of cysteine-containing peptides. Decarboxylation of OAM proceeds through oxidative addition of Pd(0) to the acyl-S bond, which accounts for the very mild reaction conditions.

2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME

The present invention relates with 2-substituted heterocyclic compounds and antitumor composition comprising the same. The compound according to the present invention exhibits superior effect as telomerase inhibitor based on new mechanism (terlomere-terlomerase) which can resolve the problems occurring at the time of using chemotherapeutics, i.e side effects and cross resistance between related mechanism on using chemotherapeutics. In addition, the antitumor composition comprising the compound of the present invention exhibits superior effect in inhibiting the growth of cancer cell.