68596-52-1

Basic information

• Product Name: Acetamide, N-(2-hydroxy-5-methoxyphenyl)-
• Synonyms: 2-(acetylamino)-4-methoxyphenol;N-(2-Hydroxy-5-methoxyphenyl)acetamide;2-acetamido-4-methoxyphenol;2-Acetamino-4-methoxy-phenol;acetic acid-(2-hydroxy-5-methoxy-anilide);Essigsaeure-(2-hydroxy-5-methoxy-anilid);N-(2-Hydroxy-5-methoxy-phenyl)-acetamide
• CAS NO: 68596-52-1
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.18900
• Mol File: 68596-52-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160.6 - 161.5 °C
• Boiling Point: 387.1±32.0 °C(Predicted)
• Density: 1.250±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Acetamide, N-(2-hydroxy-5-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(2-hydroxy-5-methoxyphenyl)-(68596-52-1)
• EPA Substance Registry System: Acetamide, N-(2-hydroxy-5-methoxyphenyl)-(68596-52-1)

Safety Data

• Hazardous Substances Data: 68596-52-1(Hazardous Substances Data)

Upstream product

• 147169-98-0 C₇H₉NO₂ 
• 5720-07-0 4-methoxyphenylboronic acid 
• 102-56-7 2,5-dimethoxyaniline 
• 1568-70-3 4-methoxy-2-nitrophenol 
• 108-24-7 acetic anhydride 
• 20734-76-3 2-amino-4-methoxyphenol 

Downstream Products

• 127285-32-9 5-methoxy-2-methoxymethoxyacetanilide 
• 475468-14-5 N-{2-[2-(2-acetylamino-4-methoxy-phenoxymethyl)-allyloxy]-5-methoxy-phenyl}-acetamide 
• 2584-06-7 4-[(E)-2-(5-Methoxy-benzooxazol-2-yl)-vinyl]-benzoic acid methyl ester 
• 1965-77-1 4-[(E)-2-(5-Methoxy-benzooxazol-2-yl)-vinyl]-benzonitrile 
• 73916-20-8 5-Methoxy-2-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzooxazole 
• 73916-19-5 5-Methoxy-2-((E)-styryl)-benzooxazole 
• 73916-21-9 2-[(E)-2-(4-Chloro-phenyl)-vinyl]-5-methoxy-benzooxazole 

Relevant articles and documents

Cp?Rh(III)/Bicyclic Olefin Cocatalyzed C-H Bond Amidation by Intramolecular Amide Transfer

A bicyclic olefin was discovered as a cocatalyst in a Cp?Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the olefin promotes a Rh(III) intermediate to undergo oxidative addition into the O-N bond to form a Rh(V) nitrenoid species and subsequently direct the nitrenoid to add to the ortho position. The amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential coupling partner for the C-H amidation. This methodology was successfully applied to the late-stage diversification of natural products and a marketed drug under mild conditions.

Novel compounds for use in weight loss and appetite suppression in humans

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

New substituted (dihydro)benzoxazine and (dihydro)benzothiazine compounds

The invention relates to compound of formula (I): wherein: G represents an alkylene chain containing from 1 to 4 carbon atoms, A represents X represents oxygen or sulphur and R2 and R1 are as defined in the description and medicinal