68617-64-1 Usage
Description
3-(2-Pyridyldithio)propanoic Acid, also known as SPDP acid, is an organic compound that contains both SPDP and carboxylic acid moieties. The SPDP group can react with amine and thiol groups, making it a versatile crosslinking agent. The carboxylic acid group can also react with primary amines in the presence of EDC and HATU to form stable amide bonds.
Uses
Used in Bioconjugation:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent for the immobilization of thrombogenesis-inhibiting enzymes on polymeric carriers. This allows for the development of biocompatible materials with enhanced bioactivity and stability.
Used in Drug Delivery:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent in the targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells. This is achieved through the formation of complexes with phosphated bovine serum albumin, which aids in the treatment of liver fibrosis.
Used in Bioconjugation Industry:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent for the immobilization of thrombogenesis-inhibiting enzymes on polymeric carriers. This application is crucial in the development of biocompatible materials with enhanced bioactivity and stability.
Used in Pharmaceutical Industry:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent in the targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells. This application is significant in the treatment of liver fibrosis, as it allows for the development of more effective drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 68617-64-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,6,1 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 68617-64:
(7*6)+(6*8)+(5*6)+(4*1)+(3*7)+(2*6)+(1*4)=161
161 % 10 = 1
So 68617-64-1 is a valid CAS Registry Number.
68617-64-1Relevant articles and documents
Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling
Digilio, Giuseppe,Menchise, Valeria,Gianolio, Eliana,Catanzaro, Valeria,Carrera, Carla,Napolitano, Roberta,Fedeli, Franco,Aime, Silvio
experimental part, p. 4877 - 4890 (2010/10/19)
Four novel MRI Gd(III)-based probes have been synthesized and evaluated for their labeling properties on cultured cell lines K562, C6, and B16. The labeling strategy relies upon the fact that cells display a large number of reactive exofacial protein thio
